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India has the world's highest prevalence of diabetes, expected to rise to 80 million by 2030. This includes many patients with lean diabetes, with low body mass index (BMI) and severe complications of diabetes. Despite its prevalence in India and other countries and its dire health consequences to individuals with the disease, little is known about the aetiopathogenesis and the genotype-phenotype relationship, lean diabetes being a cluster of low birth weight individuals, MODY, lipododystrophic disease, type 1 diabetes and fibrocalcific disease. While rudimentary tests have suggested defects in both insulin secretion and action, no comprehensive metabolic studies have been performed. It is therefore unclear as to how these patients should be treated. The optimal therapeutic adjunct whether a suitable oralantidiabetic agent or insulin is not yet determined. Defining the metabolic defects of 'lean' diabetes should have tremendous therapeutic benefit for millions of patients with this elusive condition.
Observational Model: Case Control, Time Perspective: Prospective
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Albert Einstein College of Medicine of Yeshiva University
Published on BioPortfolio: 2016-12-08T17:38:22-0500
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An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
Autoimmune diabetes in adults with slowly progressive PANCREATIC BETA CELL failure and the presence of circulating autoantibodies to PANCREATIC ISLETS cell antigens.
A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
Extracts prepared from pancreatic tissue that may contain the pancreatic enzymes or other specific uncharacterized factors or proteins with specific activities. PANCREATIN is a specific extract containing digestive enzymes and used to treat pancreatic insufficiency.
Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).