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This is a pilot biomarker study designed to compare frequencies of mutations between groups of malignant, benign and normal tissue or blood of patients with parathyroid disease and identify the potential genes showing molecular aberrations as other types of cancer.
The purpose of this study is dual-fold:
1. To determine the differences in clinical behavior and immunohistochemical (IHC) biomarkers between parathyroid carcinoma (PC), atypical neoplasm (AN) and parathyroid adenoma (PA). This will allow to use these markers as a diagnostic and screening tool when evaluating parathyroid tumors.
2. To determine which potential genes can be used in patients with parathyroid tumors for diagnostic purposes. Genomic analysis of tumor samples will be performed to identify molecular aberrations for which novel targeted therapies have been recently developed.
Immunohistochemical Profiling of Tumors
University of Texas MD Anderson Cancer Center
M.D. Anderson Cancer Center
Published on BioPortfolio: 2017-02-02T09:53:21-0500
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A technique encompassing morphometry, densitometry, neural networks, and expert systems that has numerous clinical and research applications and is particularly useful in anatomic pathology for the study of malignant lesions. The most common current application of image cytometry is for DNA analysis, followed by quantitation of immunohistochemical staining.
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