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To Study the Impact of Stopping Therapy in Patients of CML With Molecular Remission

2017-02-24 15:23:21 | BioPortfolio

Summary

Patients with chronic myeloid leukemia (CML) are conventionally put on life long therapy with tyrosine kinase inhibitor drugs (Imatinib mesylate in India). Patients who achieve a deep molecular response which has been sustained for at least three years, can be taken off the drug therapy. Thereafter a close monitoring is required to monitor their disease relapse. In case there is evidence of disease recurrence on highly sensitive molecular assays, their drug therapy is restarted. The study aims to identify proportion of patients who can be kept off drug therapy in a state of sustained molecular remission.

Description

While a large number of studies which have stopped TKI therapy in similar patients exist in Europe and USA, no such study has been done on Indian or other south Asian population. Almost all studies done previously have noted that in relapsed patients, who show disease recurrence on stopping their TKI therapy, their remission state is regained once the TKI therapy is restarted.

Study Design

Conditions

Identify Proportion of CML Patients in Treatment Free Remission

Intervention

Stopping the standard drug therpy

Status

Not yet recruiting

Source

Command Hospital, India

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-02-24T15:23:21-0500

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