Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study

2017-03-23 22:08:25 | BioPortfolio


The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders, bipolar disorders type 1 and 2) in South Korea.


The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders, bipolar disorders type 1 and 2) in South Korea. The study subjects consist of two populations: 1) patients with mood disorders under 25 years old and 2) patients with mood disorders within 2 years of treatment under 35 years old. After successful screening, the subjects are evaluated using baseline assessments and serial follow-up assessments at 3-month intervals. Between the follow-up assessments, subjects are dictated to check their own daily mood status before bedtime using the eMood chart application or a paper mood diary. In addition, wearable activity tracker(Fitbit charge series) is applied for data collection such as activity, sleep, and heart rate during every moments. At the regular visits every 3 months, inter-visit assessments are evaluated based on daily mood charts and interviews with patients. In addition to the daily mood chart, sleep quality, inter-visit major and minor mood episodes, stressful life events, and medical usage pattern with medical expenses are also assessed. Genomic DNA from blood is obtained for genomic analyses. From the MDCRC study, the clinical course, prognosis, and related factors of early-onset mood disorders can be clarified. The MDCRC is also able to facilitate translational research for mood disorders and provide a resource for the convergence study of mood disorders.

Study Design


Mood Disorders


Heon-Jeong Lee
Korea, Republic of




Korea University Anam Hospital

Results (where available)

View Results


Published on BioPortfolio: 2017-03-23T22:08:25-0400

Clinical Trials [682 Associated Clinical Trials listed on BioPortfolio]

Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies

This study looks at the role of a specific brain chemical system in the mood and attention symptoms seen in major depression and bipolar disorders using functional brain imaging.

EnBrace HR for PMS With Prominent Mood Symptoms or Menstrual Related Mood Disorders

The purpose of this study is to assess a novel nutritional supplement developed for prenatal health and mood benefits, and to determine whether there is preliminary evidence for efficacy i...

A Study of Quetiapine for the Treatment of Mood Disorders in Adolescents

The purpose of this research study is to obtain preliminary data regarding the effectiveness, tolerability, and safety of quetiapine therapy for adolescents who have a mood disorder and ha...

Online Yoga for Individuals With Mood Disorders

We are seeking to understand the acceptability of an online yoga class for individuals with mood disorders. MoodNetwork members who are 18 years old or over who have experienced depression...

Cerebellar Stroke and Mood Disorders

Post-stroke mood disorders (PSMD), including depression, anxiety and apathy, are observed in about 30 % of stroke patients at follow-up 3 or 4 months after stroke occurrence. They impair t...

PubMed Articles [5901 Associated PubMed Articles listed on BioPortfolio]

Effect of lithium on suicide and mortality in mood disorders: A systematic review.

To assess if lithium treatment in patients with mood disorders, for instance depression, bipolar disorders and schizoaffective disorders has an effect on total mortality and suicide.

Peripheral adiponectin levels in anxiety, mood, trauma- and stressor-related disorders: A systematic review and meta-analysis.

Anxiety, mood, trauma- and stressor-related disorders confer increased risk for metabolic disease. Adiponectin, a cytokine released by adipose tissue is associated with these disorders and obesity via...

Baseline cortisol and the efficacy of antiglucocorticoid treatment in mood disorders: A meta-analysis.

Hyperactivity of the Hypothalamic-Pituitary-Adrenal (HPA) axis and high cortisol levels have been widely reported in patients with mood disorders but previous clinical trials investigating the efficac...

Screening investigation of distribution of mood disorders in adolescence and peculiarities of their currency.

Introduction:. The problem of mood disorders in adolescents has recently become acute due to the high frequency of encounter and social significance. The aim: To investigate the screening of anxiety a...

Hormonal Contraceptives and Mood: Review of the Literature and Implications for Future Research.

We examine recent studies that investigate the effects of hormonal contraception on mood in different populations of women, including women in the general population and women with diagnosed psychiatr...

Medical and Biotech [MESH] Definitions

Those disorders that have a disturbance in mood as their predominant feature.

A self-administered version of the Primary Care Evaluation of Mental Disorders (PRIME-MD), a diagnostic tool containing modules on multiple mental health disorders including anxiety, alcohol, eating, and somatoform modules. The Patient Health Questionnaire (PHQ-9) is designed specifically for mood/depression scoring each of the 9 DSM-IV criteria based on the mood module from the original PRIME-MD. The Generalized Anxiety Disorder scale (GAD-7) scores 7 common anxiety symptoms.

Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.

An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.

Persons with psychiatric illnesses or diseases, particularly psychotic and severe mood disorders.

More From BioPortfolio on "Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study"

Quick Search

Relevant Topics

Bipolar Disorders
Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day-to-day tasks. Over half of Bipolar cases develops before the age of 25. Bipolar ...

Sleep Disorders
Sleep disorders disrupt sleep during the night, or cause sleepiness during the day, caused by physiological or psychological factors. The common ones include snoring and sleep apnea, insomnia, parasomnias, sleep paralysis, restless legs syndrome, circa...

Searches Linking to this Trial