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Dexmedetomidine Added to Propofol for Drug Induced Sleep Endoscopy

2017-03-27 23:08:21 | BioPortfolio

Summary

studying the effect of adding dexmedetomidine intravenous infusion to propofol intravenous infusion during sedation for drug induced sleep endoscopy

Description

In the current study 50 adult patients with obstructive sleep apnea were randomly allocated into one of two groups. Propofol group (25 patients) received only propofol infusion.Propofol-dex. group (25 patients) received dexmedetomidine intravenous infusion in addition to propofol infusion. the success of the sedation during drug induced sleep endoscopy was the primary outcome. The secondary outcomes were the sedation level as evaluated by Modified observer's assessment of alertness sedation(OAA/S) score

, the time until sufficient sedation, the total endoscopy time,the incidence of oxygen desaturation and the adverse haemodynamic effects.

Study Design

Conditions

Dexmedetomidine

Intervention

Propofol, Dexmedetomidine

Status

Not yet recruiting

Source

Zagazig University

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-03-27T23:08:21-0400

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Medical and Biotech [MESH] Definitions

An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of DEXMEDETOMIDINE.

A selective inhibitor of RECEPTORS, ADRENERGIC ALPHA-2 that has analgesic and sedative properties. MEDETOMIDINE is the other racemic form.

An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.

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