Topics

Mitochondrial Energy Metabolism in Obese Women

2017-04-19 06:08:27 | BioPortfolio

Summary

Considering that the failure of the treatment of obesity is justified by the multifactorial pathophysiology of this morbidity, the present project has the following hypotheses:

1. The occurrence of obesity is due to the derange,ent of mitochondrial energy metabolism ;

2. The unbalance is therapeutically modified through physical training ;

3. Obesity courses with the break-down in energy metabolism mitochondrial disease associated with systemic inflammatory characteristics that can be corrected through a combined long-term physical training program.

This study have as objective : to analyse changes in mitochondrial function, inflammatory profile, oxidative stress and energy metabolism caused by concurrent physical training in obese women.

Description

Specific objectives:

Body composition by deuterium oxide; Metabolic rate of resting and oxidation of substrates by indirect calorimetry; Proinflammatory cytokines Anti-inflammatory cytokines Oxidative Stress: Malondialdehyde, Superoxide Dismutase, Glutathione-Peroxidase; Fatty acids: ceramide and palmitate; Mitochondrial respiration and citrate synthase enzyme; Quantify and qualify: mitochondrial number, endoplasmic reticulum structure, adipose cell size; Gene expression, quantify by microscopy and analyze the protein by western blot.

The study began with 20 women, however, there was withdrawal of 6, ending with 14 women.

Study Design

Conditions

Metabolism Disorder

Intervention

Physical Training

Location

Camila Fernanda Cunha Brandão
Ribeirao Preto
SP
Brazil
14.048-900

Status

Completed

Source

University of Sao Paulo

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-04-19T06:08:27-0400

Clinical Trials [3983 Associated Clinical Trials listed on BioPortfolio]

Effect of Physical Training Program on Health-related Quality of Life in Cirrhosis

Physical training improves quality of life (QOL) in non-hepatic diseases. It is possible that the same effect happens in patients with cirrhosis and portal hypertension. Hepatic encephalop...

Resistance Training to Improve Fatigue and Physical Function in Postmenopausal Breast Cancer Survivors

This study will begin to fill a knowledge gap by determine whether changes in kynurenine metabolism occur following Resistance Training (RT) and relate to reductions in inflammation and im...

Exercise Training as Medicine for Substance Use Disorder Patients

This study compares the effects of high dose and low dose, high intensity, endurance training and strength training in substance use disorder patients. The hypothesis is that the increase ...

Exercise Training and Hepatic Metabolism in Overweight/Obese Adolescent

The HEPAFIT Study aims to examine whether a 6-months physical education program has benefits on hepatic metabolism and cardiovascular health as well as on selected physical fitness and men...

The Role of Brain-derived Neurotropic Factor in the Relationship Between Executive Function and Physical Training

This doctoral thesis has the aim to identify the role of Brain-derived neurotropic factor in the relationship between physical fitness/activity and executive functions in typically develop...

PubMed Articles [17602 Associated PubMed Articles listed on BioPortfolio]

Physical Exercise Training Improves Quality of Life in Healthy Older Adults: A Meta-Analysis.

The current meta-analysis first aimed to quantify the overall effect of physical exercise training on the quality of life (QoL) in healthy older adults. Second, the effects on the social, physical, an...

Effects of physical training in patients with type 2 diabetes mellitus: a systematic review.

Physical training is recommended in several studies and guidelines for the control of type 2 diabetes mellitus (DM2) and its complications. We performed a systematic review about the effects of aerobi...

Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia.

Intestinal metabolism and microbiota profiles are impaired in obesity and insulin resistance. Moreover, dysbiotic gut microbiota has been suggested to promote systemic low-grade inflammation and insul...

Effects of Physical Exercise Training in the Workplace on Physical Fitness: A Systematic Review and Meta-analysis.

There is evidence that physical exercise training (PET) conducted at the workplace is effective in improving physical fitness and thus health. However, there is no current systematic review available ...

Multimodal Training Reduces Fall Frequency as Physical Activity Increases in Individuals With Parkinson's Disease.

Parkinson's disease (PD) results in a global decrease in information processing, ultimately resulting in dysfunction executing motor-cognitive tasks. Motor-cognitive impairments contribute to postural...

Medical and Biotech [MESH] Definitions

A disorder whose predominant feature is a loss or alteration in physical functioning that suggests a physical disorder but that is actually a direct expression of a psychological conflict or need.

Financial support for training including both student stipends and loans and training grants to institutions.

Instructional programs in the care and development of the body, often in schools. The concept does not include prescribed exercises, which is EXERCISE THERAPY.

An X-linked disorder characterized by HYPOPHOSPHATEMIA; RICKETS; OSTEOMALACIA; renal defects in phosphate reabsorption and vitamin D metabolism; and growth retardation. This disorder is caused by mutations in PHEX PHOSPHATE REGULATING NEUTRAL ENDOPEPTIDASE.

On the job training programs for personnel carried out within an institution or agency. It includes orientation programs.

More From BioPortfolio on "Mitochondrial Energy Metabolism in Obese Women"

Quick Search

Relevant Topics

Obesity
Obesity is the condition in which excess fat has accumulated in the body (mostly in subcutaneous tissues). clinical obesity is considered to be present when a person has a BMI of over 30 (Oxford Dictionary of Medicine). It is becoming increasing common i...

Public Health
Alternative Medicine Cleft Palate Complementary & Alternative Medicine Congenital Diseases Dentistry Ear Nose & Throat Food Safety Geriatrics Healthcare Hearing Medical Devices MRSA Muscular Dyst...


Searches Linking to this Trial