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Transplantation of Fibroblast for Correction of Nasolabial Folds

2017-05-05 11:53:22 | BioPortfolio

Summary

he study evaluated the safety and efficacy of the Autologous cultured fibroblast for correction of Nasolabial folds and inhibition of skin aging

Description

Autologous cultured fibroblast which is obtain from the patient's normal skin is harvested and expanded in an in vitro. Biopsies samples are obtained from the behind of the patient's ear as a source of fibroblasts, then fibroblast cells isolated and expanded through cell culture, and used for the correction of Nasolabial folds, deep wrinkles of the forehead. Prior to final packaging, cell viability is assessed to be at least 85%

Study Design

Conditions

Nasolabial Folds

Intervention

Fibroblast, Placebo

Location

Stem cell and Regenerative Medicine institute (SCARM)
Tabriz
Iran, Islamic Republic of

Status

Not yet recruiting

Source

Stem Cell and Regenerative Medicine Institute, Tabriz, Iran

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-05-05T11:53:22-0400

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PubMed Articles [1629 Associated PubMed Articles listed on BioPortfolio]

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Finite-Element Biomechanical-Simulated Analysis of the Nasolabial Fold.

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Evaluation Of Nasolabial Aesthetics By Different Groups In Operated Unilateral Cleft Lip And Palate.

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Medical and Biotech [MESH] Definitions

A fibroblast growth factor receptor that is found in two isoforms. One receptor isoform is found in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform of fibroblast growth factor receptor 2 is found mainly in EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in APERT SYNDROME.

The most divergent of the known fibroblast growth factor receptors. It does not contain an intracellular TYROSINE KINASE domain and has been shown to interact with FIBROBLAST GROWTH FACTOR 2. Fibroblast growth factor receptor 5 is found primarily in skeletal tissue.

A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM.

A fibroblast growth factor that was initially identified based on its sequence similarity to FIBROBLAST GROWTH FACTOR 4. It is found in MYOBLASTS and plays an important role in MUSCLE DEVELOPMENT.

A fibroblast growth factor that is a specific mitogen for EPITHELIAL CELLS. It binds a complex of HEPARAN SULFATE and FIBROBLAST GROWTH FACTOR RECEPTOR 2B.

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