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PK and DPK of Lidocaine Dermal Products

2017-05-10 13:53:22 | BioPortfolio

Summary

This is a bioequivalence study to compare lidocaine release between a brand name and generic skin patches in healthy adults.

Description

This research study is intended to determine the effect of heat on lidocaine patches. This study will use lidocaine patches (brand name and generic patches) that have been approved by the Food and Drug Administration (FDA) and are already sold to customers in the United States, and will not include any placebos.

Study Design

Conditions

Heat Effect

Intervention

Lidocaine patch

Location

General Clinical Research Center (GCRC) at the University of
Baltimore
Maryland
United States
21201

Status

Recruiting

Source

University of Maryland

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-05-10T13:53:22-0400

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PubMed Articles [11711 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.

The application of heat to raise the temperature of the environment, ambient or local, or the systems for accomplishing this effect. It is distinguished from HEAT, the physical property and principle of physics.

A medicated adhesive patch placed on the skin to deliver a specific dose of medication into the bloodstream.

Skin tests in which the sensitizer is applied to a patch of cotton cloth or gauze held in place for approximately 48-72 hours. It is used for the elicitation of a contact hypersensitivity reaction.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

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