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Expression of Protein Convertases in Thyroid Nodules

2017-05-21 16:06:37 | BioPortfolio

Summary

Nowadays, the investigation of thyroid nodules is limited by the fact that up to 49% of the fine needle aspirations (FNA) performed on them are of "indeterminate cytological signification". Moreover, no reliable molecular marker for thyroid cancer have been developed up to this day. The goal of this project is to study the expression of a specific kind of protein convertase in benign and in malignant thyroid nodules to determine its potential as a clinically useful biomarker.

Description

Patients that underwent total of subtotal thyroidectomy at the CIUSSS de l'Estrie-CHUS will be recruited and classified according to the pathological diagnosis. An immunohistochemistry technique, developed and calibrated for the specific protein convertase studied, will be undertaken. Results will be interpreted by a specialized pathologist.

Study Design

Conditions

Thyroid Nodule

Intervention

Immunohistochemistry

Location

CIUSSS de l'Estrie - CHUS
Sherbrooke
Quebec
Canada
J1G 2E8

Status

Enrolling by invitation

Source

Université de Sherbrooke

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-05-21T16:06:37-0400

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Medical and Biotech [MESH] Definitions

An enlarged THYROID GLAND containing multiple nodules (THYROID NODULE), usually resulting from recurrent thyroid HYPERPLASIA and involution over many years to produce the irregular enlargement. Multinodular goiters may be nontoxic or may induce THYROTOXICOSIS.

A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).

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