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Skeletal Muscle Expression of Myostatin and Colon Cancer Associated Cachexia

2017-06-01 19:08:21 | BioPortfolio

Summary

Cancer cachexia is responsible for the death of approximately 20% of patients. Myostatin is a master negative regulator of skeletal muscle mass. If the role of myostatin in cancer cachexia is now well established in murine models, no study has focused on muscle expression of Myostatin in relation to the degree of cachexia. the hypothesize is that muscle Myostatin a biological marker of cachexia in patients with colon cancer. The main objective is to compare skeletal muscle Myostatin messenger RiboNucleic Acid (mRNA) level as a function of cachexia in colon cancer patients. Myostatin messenger RiboNucleic Acid (mRNA) level will be determined in a muscle sample taken during the resection under general anaesthesia. Skeletal muscle index will be determined before surgery, 3 and 6 months after surgery. Muscle strength of the lower and upper limbs will be determined before resection, at 1 month, 3 months and 6 months postoperatively. Blood sampling will also be performed on these 4 occasions.

Study Design

Conditions

Colon Cancer

Intervention

Height and weight, Blood samples, Skeletal muscle force, Skeletal muscle index, Muscle biopsy

Location

CHU Saint-Etienne
Saint-Étienne
France
42055

Status

Not yet recruiting

Source

Centre Hospitalier Universitaire de Saint Etienne

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-06-01T19:08:21-0400

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