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Until now very little information exists regarding the early luteal serum progesterone profile after Human chorionic gonadotropin (hCG) trigger. This pilot-study will help characterize the serum progesterone profiles in IVF patients and correlate progesterone levels to ovarian follicles obtained after stimulation with exogenous gonadotropins.
The early luteal phase after IVF treatment is only scarcely studied (Ragni et al., 2001; Fauser et al., 2002; Beckers et al., 2003, Humaidan et al., 2012). During IVF treatment the early luteinizing hormone (LH) activity deficit induced after ovarian stimulation with exogenous gonadotropins will be partly covered by the bolus of hCG used for triggering of final oocyte maturation due to the long half-life of hCG (Weissman et al., 1996; Fauser et al., 2002; Andersen C.Y and Vilbour Andersen, 2014). In addition, the luteal phase will be covered by exogenous progesterone supplementation. After successful implantation the embryo itself will provide the supportive LH activity, securing the function of the corpora lutea. However, during early luteal phase and peri-implantation recent data suggest that an early-mid-luteal hCG/LH deficiency exists after hCG trigger during which the corpus luteum lacks an optimal stimulation (Andersen CY and Vilbour Andersen, 2014). Furthermore, the early luteal progesterone profile in IVF differs significantly from the progesterone profile of the natural cycle, in which the peak is reached around the time of implantation. With this non-invasive trial we wish to further explore the early luteal phase profiles of progesterone and hCG in order to optimize current luteal phase support policies in IVF and hopefully increase ongoing pregnancy rates.
My Duc Hospital
Ho Chi Minh City
Not yet recruiting
Vietnam National University
Published on BioPortfolio: 2017-06-04T19:40:10-0400
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