Topics

Early Luteal Progesterone Profile in IVF Patients Triggered With hCG

2017-06-04 19:40:10 | BioPortfolio

Summary

Until now very little information exists regarding the early luteal serum progesterone profile after Human chorionic gonadotropin (hCG) trigger. This pilot-study will help characterize the serum progesterone profiles in IVF patients and correlate progesterone levels to ovarian follicles obtained after stimulation with exogenous gonadotropins.

Description

The early luteal phase after IVF treatment is only scarcely studied (Ragni et al., 2001; Fauser et al., 2002; Beckers et al., 2003, Humaidan et al., 2012). During IVF treatment the early luteinizing hormone (LH) activity deficit induced after ovarian stimulation with exogenous gonadotropins will be partly covered by the bolus of hCG used for triggering of final oocyte maturation due to the long half-life of hCG (Weissman et al., 1996; Fauser et al., 2002; Andersen C.Y and Vilbour Andersen, 2014). In addition, the luteal phase will be covered by exogenous progesterone supplementation. After successful implantation the embryo itself will provide the supportive LH activity, securing the function of the corpora lutea. However, during early luteal phase and peri-implantation recent data suggest that an early-mid-luteal hCG/LH deficiency exists after hCG trigger during which the corpus luteum lacks an optimal stimulation (Andersen CY and Vilbour Andersen, 2014). Furthermore, the early luteal progesterone profile in IVF differs significantly from the progesterone profile of the natural cycle, in which the peak is reached around the time of implantation. With this non-invasive trial we wish to further explore the early luteal phase profiles of progesterone and hCG in order to optimize current luteal phase support policies in IVF and hopefully increase ongoing pregnancy rates.

Study Design

Conditions

Progesterone

Intervention

Blood collection

Location

My Duc Hospital
Ho Chi Minh City
Vietnam
70000

Status

Not yet recruiting

Source

Vietnam National University

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-06-04T19:40:10-0400

Clinical Trials [854 Associated Clinical Trials listed on BioPortfolio]

Variation of Progesterone in IVF Cycles

to examine if a natural daytime variation in progesterone levels may explain parts of the inconsistent findings from studies reporting divergent results concerning this matter and will be ...

Progesterone Variation on the Final Day of Oocyte Maturation.

The current study, aims through a robust design to provide a simple answer on whether progesterone levels of the same individual may significantly vary depending on the time of blood retri...

Effects of Raloxifene on Hormone Levels

Blood levels of the hormones estradiol and progesterone are of interest in evaluating ovarian function. However, because these hormone levels vary from day to day, blood samples must be t...

Vasomotor Symptoms (VMS) Progesterone Study: Vasomotor Symptoms and Endothelial Function - Trial of Oral Micronized Progesterone

The primary purpose of this study is to determine the effects of a full dose (300 mg at hs) of oral micronized progesterone (OMP) on vasomotor symptoms [VMS] (hot flushes/night sweats), on...

Serum Progesterone on the Day of Thawed Embryo Transfer and Pregnancy Rate After an Artificial Endometrial Preparation

To determine if different serum Progesterone levels on FET day are associated with different clinical pregnancy rates (CPR), and if increasing dosage of vaginal Progesterone in cases of lo...

PubMed Articles [7913 Associated PubMed Articles listed on BioPortfolio]

Feasibility of echocardiography-guided repeated intraventricular blood sampling in mice.

To investigate the feasibility of echocardiography-guided closed-chest repeated intraventricular blood sampling in mice, and to clarify the maximum blood volume that can be collected by this method, a...

Slowing decline in blood collection and transfusion in the United States - 2017.

The National Blood Collection and Utilization Survey (NBCUS) has demonstrated declines in blood collection and transfusion in the United States since 2008, including declines of 11.6% in red blood cel...

Gene expression profiling of whole blood: A comparative assessment of RNA-stabilizing collection methods.

Peripheral Blood gene expression is widely used in the discovery of biomarkers and development of therapeutics. Recently, a spate of commercial blood collection and preservation systems have been intr...

Progesterone decreases apnoea and reduces oxidative stress induced by chronic intermittent hypoxia in ovariectomized female rats.

What is the central question of this study? Does progesterone reduce the effect of chronic intermittent hypoxia (CIH) on arterial blood pressure, respiratory control, and oxidative stress in the centr...

Reply to Verougstraete et al. Comment on HbA determination from HemaSpot blood collection devices: comparison of home-prepared dried blood spots with standard venous blood analysis.

In response to the letter from Verougstraete et al. [1] regarding our publication 'HbA1c determination from HemaSpot blood collection devices: comparison of home-prepared dried blood spots with standa...

Medical and Biotech [MESH] Definitions

Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.

Development of a library collection, including the determination and coordination of selection policy, assessment of needs of users and potential users, collection use studies, collection evaluation, identification of collection needs, selection of materials, planning for resource sharing, collection maintenance and weeding, and budgeting.

Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.

The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.

A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.

More From BioPortfolio on "Early Luteal Progesterone Profile in IVF Patients Triggered With hCG"

Quick Search

Relevant Topics

Endocrine Disorders
Endocrine disorders are grouped into two categories: hormone imbalance - when a gland produces too much or too little of an endocrine hormone development of lesions (such as nodules or tumors) in the endocrine system, which may or may not affect...

Obstetrics and gynaecology
Fertility Menopause Obstetrics & Gynaecology Osteoporosis Women's Health Obstetrics and gynaecology comprises the care of the pregnant woman, her unborn child and the management of diseases specific to women. Most consultant...


Searches Linking to this Trial