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Lower Lugol's Solution Concentration on Reducing the Adverse Symptoms of Chromoendoscopy With Iodine Staining

2017-06-08 20:38:22 | BioPortfolio

Summary

This study was to test an appropriate concentration of Lugol's solution which can reduce the mucosal irritation and provide high image quality to ensure endoscopy examination by a randomized blinded controlled trial.

Description

It is widely accepted that chromoendoscopy using Lugol's solution is effective for the detection of early esophageal squamous neoplasia. However, this modality may cause severe chest pain and discomfort owing to mucosal irritation. The conventional concentration of Lugol's solution is in the range of 1.2% to 2.5% . Image quality can be guaranteed with this range of Lugol's solution. However, lead to retrosternal pain and discomfort, and can even induce erosion or ulceration in the esophagus and stomach. This study was to test whether a lower concentration of Lugol's solution, which has minimal mucosal irritation, can provide satisfied image quality by a randomized blinded controlled trial.

Study Design

Conditions

Mucosal Irritation

Intervention

1.2% Lugol's solution, 1.0% Lugol's solution, 0.8% Lugol's solution, 0.6% Lugol's solution, 0.4% Lugol's solution

Location

Qilu Hospital, Shandong University
Jinan
Shandong
China
250012

Status

Not yet recruiting

Source

Shandong University

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-06-08T20:38:22-0400

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Medical and Biotech [MESH] Definitions

Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).

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