Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment

2017-06-08 20:38:22 | BioPortfolio



Due to the remarkable improvement in treatments these last decades, long term survival can be expected in more than 80% of childhood cancer patients. Unfortunately, cancer treatments can be harmful to the gonads and can affect reproductive and endocrine functions. While loss of fertility is a major concern for most patients, sperm cryopreservation should be offered to all pubertal male patients. For prepubertal boys, only the experimental option of testicular biopsy in order to cryopreserve testicular stem cells can be proposed.

Primary aims

- To cryopreserve testicular tissue of prepubertal patient receiving highly gonadotoxic oncological treatment.

Secondary aims

- To cryopreserve testicular tissue after failure of sperm cryopreservation in pubertal patient with high risk of infertility

- To create a database in order to record clinical and biological follow-up data

- To create a research biobank for future research projects

Multicentric study: HUG, CHUV, UKBB

Study Design


Childhood Cancer


testicular tissue biopsy






University Hospital, Geneva

Results (where available)

View Results


Published on BioPortfolio: 2017-06-08T20:38:22-0400

Clinical Trials [2529 Associated Clinical Trials listed on BioPortfolio]

Testicular Tissue Cryopreservation for Fertility Preservation

Testicular tissue cryopreservation is an experimental procedure where a young boy's testicular tissue is retrieved and frozen. This technique is reserved for young male patients who are no...

Fertility Preservation in Prepubertal Boys: An Experimental Approach

Due to remarkable advances in cancer treatments, the investigators are witnessing a growing population of long-term survivors of childhood malignancies. However, fertility in adult life ma...

Testicular Tissue Cryopreservation in Children

The IRB protocol is being designed to offer testicular tissue cryopreservation to male pediatric patients (0-17 years of age) with fertility threatening medical diagnoses or facing surgery...

Testicular Tissue Cryopreservation for Fertility Preservation in Male Patients Facing Infertility-causing Diseases or Treatment Regimens

Many chemotherapy and radiation-containing regimens for cancer or prior to bone marrow transplantation can cause sterility in children and young adults. In addition, some human disease con...

Diagnostic Study of Patients With Stage I Testicular Cancer

RATIONALE: Diagnostic procedures may improve a doctor's ability to predict the recurrence of testicular cancer. PURPOSE: Diagnostic trial to detect the risk of recurrent disease in patien...

PubMed Articles [22051 Associated PubMed Articles listed on BioPortfolio]

Cellular origin of microRNA-371a-3p in healthy males based on systematic urogenital tract tissue evaluation.

The microRNA-371a-3p (miR-371a-3p) has been reported to be an informative liquid biopsy (serum and plasma) molecular biomarker for both diagnosis and follow-up of patients with a malignant (testicular...

Awareness of clinical relevance of malignant testicular cancer among university students : The value of ​prevention campaigns.

Early detection of localized testicular cancer is associated with a significantly better prognosis compared to advanced tumor stages. Testicular cancer prevention campaigns like "" launc...

Testicular sperm extraction in men with sertoli cell-only testicular histology - 1680 cases.

To study the outcomes of testicular sperm extraction (TESE) among men with pure Sertoli cell-only histology identified during diagnostic testicular biopsy.

The rising incidence of testicular cancer among young men in Canada, data from 1971-2015.

Testicular cancer is the most common malignancy among young men aged 15-44 in Canada. The goal of this analysis was to examine age-period-cohort effects of testicular cancer incidence between 1971 and...

MRI in the Follow-up of Testicular Cancer: Less is More.

This study aimed to report the location of abdominal relapse in patients with testicular cancer.

Medical and Biotech [MESH] Definitions

Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.

A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show infiltration of LYMPHOCYTES in the superficial EPITHELIUM and the underlying connective tissue (lamina propria).

Progressive myopathies characterized by the presence of inclusion bodies on muscle biopsy. Sporadic and hereditary forms have been described. The sporadic form is an acquired, adult-onset inflammatory vacuolar myopathy affecting proximal and distal muscles. Familial forms usually begin in childhood and lack inflammatory changes. Both forms feature intracytoplasmic and intranuclear inclusions in muscle tissue. (Adams et al., Principles of Neurology, 6th ed, pp1409-10)

Conducting a biopsy procedure with the aid of a MEDICAL IMAGING modality.

Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.

More From BioPortfolio on "Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment"

Quick Search

Relevant Topics

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...

Searches Linking to this Trial