Non-immune Related Hypothyroidism: A Major Cause of Hypothyroidism in Iodine Sufficient Areas

2017-06-08 20:38:22 | BioPortfolio


Background: Autoimmune hypothyroidism has been regarded as the most common cause of primary hypothyroidism in iodine sufficient area and has relationship with excess iodine induced hypothyroidism. However, non-immune related hypothyroidism and its relationship with excess iodine have been rarely evaluated.

Objective: Therefore, we planned to calculate proportion of non-immune related hypothyroidism and relationship with iodine intake using nationwide data from Korea National Health and Nutrition Examination Survey (KNHANES) 2013-2015.


1. Korea National Health and Nutrition Examination Survey VI (2013 to 2015) - The national data which is a the government designated statistics (Approval No. 117002 ) of South Korea based on the Article 17 of the National Health Promotion Act - were used. The survey was approved by the Institutional Review Board of the Korea Centers for Disease Control and Prevention, and provides only non-identified measures for academic research purposes.

2. The participants who were examined for thyroid stimulating hormone, free thyroxine, thyroid peroxidase antibody (TPO Ab), and urine iodine concentration (UIC) were included.

3. The proportion of immune related and non-immune related hypothyroidism was evaluated. Demographic variables and severity of hypothyroidism were compared between the two groups. To analyze iodine effect on hypothyroidism in TPO Ab positive or negative population, prevalence of hypothyroidism were assessed in each TPO Ab negative and positive population according to UIC subgroups.

4. This study protocol was approved by IRB of SMC (2017-05-149).

Study Design




We did not apply any intervention for the participants.




Samsung Medical Center

Results (where available)

View Results


Published on BioPortfolio: 2017-06-08T20:38:22-0400

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