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Ciliation and Mucus Rheology Parameters Determined Via Air-liquid-interface Cell Cultures in Non-smoking, Smoking, COPD and Asthmatic Patients

2017-06-16 01:53:21 | BioPortfolio

Summary

This is a prospective study comparing 4 groups: (1) non-smoking controls, (2) smokers without chronic obstructive pulmonary disease (COPD), (3) smokers with COPD, (4) severe asthma.

Bronchial biopsy specimens from each subject will be obtained to produce air-liquid-interface cell cultures. These will then be used to make observations concerning cilia and mucus rheology.

This is a first pilot study. We hypothesize that the largest group differences will be found for cilia densities, and have thus chosen evaluating this metric as a primary criterion.

Study Design

Conditions

Pulmonary Disease, Chronic Obstructive

Intervention

Bronchial Biopsy, ALI culture

Location

Centre Hospitalier Universitaire de Montpellier
Montpellier
France
34295

Status

Not yet recruiting

Source

University Hospital, Montpellier

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-06-16T01:53:21-0400

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