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The investigators aimed to evaluate the effect of AMCPR (Augmented-Medication CardioPulmonary Resuscitation: administration of additional vasopressin to titrate to arterial diastolic blood pressure over 20 mmHg) on cardiopulmonary resuscitation results and outcomes in out-of-hospital cardiac arrest patients.
Non-traumatic out-of-hospital cardiac arrest patients receive standard advanced cardiac life support according to the 2015 AHA guideline, including chest compression, intubation, ventilation, defibrillation, drug administration, including epinephrine and antiarrhythmic drugs if indicated, in the emergency department.
A research associate generates a random sequence using Excel software, and assignment of participants to their respective groups will be undertaken by the principal investigator.
Arterial line insertion is performed within 6 minutes after randomization and diastolic blood pressure will be monitored.
If diastolic blood pressure is < 20 mmHg, drugs (vasopressin 40 IU or normal saline) will be administered for two times during CPR.
Arterial blood gas analysis will be analyzed for 5, 10, 15, and 20 minutes after arterial line insertion or termination of CPR.
End-tidal carbon dioxide concentrations is monitored in real time during CPR and recorded every minute.
The resuscitated patients receive standard post cardiac arrest care according to the 2015 AHA guideline.
Out-of-Hospital Cardiac Arrest
Vasopressins, Normal saline
Chonnam National University Hospital
Korea, Republic of
Not yet recruiting
Asan Medical Center
Published on BioPortfolio: 2017-06-20T02:08:21-0400
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Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.
Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
The omission of atrial activation that is caused by transient cessation of impulse generation at the SINOATRIAL NODE. It is characterized by a prolonged pause without P wave in an ELECTROCARDIOGRAM. Sinus arrest has been associated with sleep apnea (REM SLEEP-RELATED SINUS ARREST).
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cardiac patient.
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