AMCPR (Augmented-Medication CardioPulmonary Resuscitation) Trial for OHCA

2017-06-20 02:08:21 | BioPortfolio


The investigators aimed to evaluate the effect of AMCPR (Augmented-Medication CardioPulmonary Resuscitation: administration of additional vasopressin to titrate to arterial diastolic blood pressure over 20 mmHg) on cardiopulmonary resuscitation results and outcomes in out-of-hospital cardiac arrest patients.


Non-traumatic out-of-hospital cardiac arrest patients receive standard advanced cardiac life support according to the 2015 AHA guideline, including chest compression, intubation, ventilation, defibrillation, drug administration, including epinephrine and antiarrhythmic drugs if indicated, in the emergency department.

A research associate generates a random sequence using Excel software, and assignment of participants to their respective groups will be undertaken by the principal investigator.

Arterial line insertion is performed within 6 minutes after randomization and diastolic blood pressure will be monitored.

If diastolic blood pressure is < 20 mmHg, drugs (vasopressin 40 IU or normal saline) will be administered for two times during CPR.

Arterial blood gas analysis will be analyzed for 5, 10, 15, and 20 minutes after arterial line insertion or termination of CPR.

End-tidal carbon dioxide concentrations is monitored in real time during CPR and recorded every minute.

The resuscitated patients receive standard post cardiac arrest care according to the 2015 AHA guideline.

Study Design


Out-of-Hospital Cardiac Arrest


Vasopressins, Normal saline


Chonnam National University Hospital
Korea, Republic of


Not yet recruiting


Asan Medical Center

Results (where available)

View Results


Published on BioPortfolio: 2017-06-20T02:08:21-0400

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The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cardiac patient.

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