IV Acetaminophen for Post-Operative Pain Management in Enhanced Recovery After Surgery (ERAS) Population

2017-06-27 05:08:22 | BioPortfolio


The primary goal of this study is to assess the utility of a postoperative intravenous acetaminophen dosing schedule in minimizing postoperative pain, opioid consumption and opioid-related side effects. We also aim to study overall patient satisfaction and cost-effectiveness (direct and indirect costs) of this regimen as part of Enhanced Recovery After Surgery protocol at the University of Pittsburgh Medical Center (UPMC) Presbyterian Hospital, a tertiary care hospital and level one trauma center.


In response to an increased focus on improving patient outcomes and satisfaction with surgical care, a growing body of clinical evidence has recently been dedicated to enhanced recovery after surgery (ERAS) protocols. These evidence-based perioperative pathways aim to optimize patients undergoing surgery in the preoperative, intraoperative, and postoperative periods. Intravenous acetaminophen has been of interest for its utility in post-surgical patients, who have not yet been cleared for oral intake. Intravenous acetaminophen should also be preferred over oral acetaminophen in patients after major abdominal surgery where absorption of medications given through oral route is erratic. For this trial, patients will be randomized to receive a regimented IV acetaminophen or placebo dose in addition to standard of care opioids for pain control following abdominal procedures.

Study Design


Abdominal Wall Hernia


Acetaminophen Injectable Product, Sodium Chloride 0.9%, Intravenous


Not yet recruiting


University of Pittsburgh

Results (where available)

View Results


Published on BioPortfolio: 2017-06-27T05:08:22-0400

Clinical Trials [3250 Associated Clinical Trials listed on BioPortfolio]

Hypertonic Saline Resuscitation in Trauma Patients After Hemorrhage Control

The purpose of this study is to determine whether hypertonic saline solution is effective in the resuscitation of traumatized patients undergone abdominal damage control surgery regarding ...

Sodium Chloride and Contrast Nephropathy

This phase II, open, non-inferiority, randomized and controlled clinical trial is aimed to ascertain the incidence of contrast nephropathy in outpatients undergoing CT scan with contrast. ...

Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study

Study assessing efficacy and safety of concomitantly dosed naproxen sodium with acetaminophen, compared with naproxen sodium, hydrocodone/acetaminophen and Placebo in a postoperative denta...

Abdominal Wall Transplant

The purpose of this protocol is to determine the safety and efficacy of abdominal wall transplantation as a treatment for the reconstruction of abdominal wall defects. Abdominal wall trans...

Determine the Clinical Advantage of IV vs PO Acetaminophen

There is limited research on the clinical outcome differences between intravenous (IV) acetaminophen versus oral (PO) acetaminophen. With the costs of intravenous acetaminophen sometimes b...

PubMed Articles [8648 Associated PubMed Articles listed on BioPortfolio]

Performance of biological mesh materials in abdominal wall reconstruction: study protocol for a randomised controlled trial.

Abdominal wall hernias are a common source of morbidity and mortality. The use of biological mesh has become an important adjunct in successful abdominal wall reconstruction. There are a variety of bi...

Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass.

Children undergoing cardiac surgery often receive acetaminophen (paracetamol) as part of their postoperative pain treatment. To date, there is no information on the pharmacokinetics (PK) of acetaminop...

Recognizing abdominal wall endometriosis.

Abdominal wall endometriosis is ectopic endometrial tissue in the abdominal wall. Consider this condition in any woman presenting with chronic abdominal pain and a surgical history significant for exp...

Autointoxication with 'suicide powder'.

We present two patients who were treated for an intentional overdose of sodium nitrite. When ingested sodium nitrite leads to severe methaemoglobinaemia, resulting in severe hypoxia (as methaemoglobin...

Dynamic creep properties of a novel nanofiber hernia mesh in abdominal wall repair.

Incisional hernia is the most common complication following abdominal surgery. While mesh repair is common, none of the current meshes mimic the physiology of the abdominal wall. This study compares s...

Medical and Biotech [MESH] Definitions

A protrusion of abdominal structures through the retaining ABDOMINAL WALL. It involves two parts: an opening in the abdominal wall, and a hernia sac consisting of PERITONEUM and abdominal contents. Abdominal hernias include groin hernia (HERNIA, FEMORAL; HERNIA, INGUINAL) and VENTRAL HERNIA.

A subclass of symporters that specifically transport SODIUM CHLORIDE and POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process.

Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.

The outer margins of the ABDOMEN, extending from the osteocartilaginous thoracic cage to the PELVIS. Though its major part is muscular, the abdominal wall consists of at least seven layers: the SKIN, subcutaneous fat, deep FASCIA; ABDOMINAL MUSCLES, transversalis fascia, extraperitoneal fat, and the parietal PERITONEUM.

Sodium chloride used in foods.

More From BioPortfolio on "IV Acetaminophen for Post-Operative Pain Management in Enhanced Recovery After Surgery (ERAS) Population"

Quick Search

Relevant Topic

Pain is defined by the International Association for the Study of Pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage”. Some illnesses can be excruci...

Searches Linking to this Trial