The Juice Study: Sensitivity of Skin Carotenoid Status to Detect Change in Intake

2017-06-29 05:53:21 | BioPortfolio


This study is designed to see if drinking a tomato-based vegetable juice will increase skin carotenoids.


The US Dietary Guidelines for Americans recommends that individuals consume approximately 2-4 c of vegetables each day to reduce risk of chronic disease, but current methods for assessing intake are either inaccurate (self-report) or invasive (blood carotenoid levels). Recent research indicates that skin carotenoid status may be a useful biomarker of vegetable intake, but the sensitivity to dose in unknown. In this study, we propose to test the dose-response of skin carotenoids to consumption of 3 different levels of vegetable juice (with a control group receiving water). We will test skin carotenoids in two ways: using resonance Raman spectroscopy (RRS), which we have previously validated, and with a new technique, pressure mediated reflection spectroscopy (RS; the "Veggie Meter"). We will compare the two techniques during an 8-week provided tomato-based juice intervention. Skin carotenoid readings will be compared to blood carotenoid concentrations and single nucleotide polymorphisms (SNPs) of genes related to the uptake, transport, and metabolism of carotenoids will be examined in blood and saliva.

Study Design




High dose vegetable juice, Medium dose vegetable juice, Low dose vegetable juice, Control bottled water


USDA Grand Forks Human Nutrition Research Center
Grand Forks
North Dakota
United States




USDA Grand Forks Human Nutrition Research Center

Results (where available)

View Results


Published on BioPortfolio: 2017-06-29T05:53:21-0400

Clinical Trials [6086 Associated Clinical Trials listed on BioPortfolio]

Clinical Investigation on the Effects of a Vegetable Juice Treatment

The purpose of the investigators study is to investigate the impact of a commercial vegetable juice on dietary vegetable intake and select cardiovascular risk factors in a generally health...

Effect of Nitrate-rich Fruit and Vegetable Supplement on Blood Pressure

It is hypothesized that the daily supplementation of a nitrate-rich, two-ounce fruit and vegetable energy supplement (Isagenix International LLC) by healthy young adults with a would incre...

Effect of Dietary Intake of Dried Whole Food Concentrates (Juice Plus) on Clinical Outcomes Following Periodontal Therapy: A Pilot Study

There are 3 hypotheses to be tested: 1. That daily supplementation with Juice Plus+ will significantly improve treatment outcomes over placebo supplementation, at 3-months post-the...

Fruit and Vegetable Juice Concentrate Effects on RBP4 and Antioxidant Capacity in Lean and Overweight 6-10 Year Old Boys

Our study aims to evaluate if the consumption of a Fruit and Vegetable Juice Concentrate (FVJC) vs. placebo can exert changes in the serum levels of Retinol Binding Protein 4 (RBP4), carot...

Fruit And Vegetables and OUtcomes After Removal of Impacted TEeth

The proposed study will test the following hypotheses: 1. Pre-operative daily dual supplementation with Juice Plus+ (fruit & vegetable) for 11 weeks will result in reduced post-ope...

PubMed Articles [18640 Associated PubMed Articles listed on BioPortfolio]

Juice Displaces Milk and Fruit in High School Lunches.

To compare beverages and foods selected by high school students on days when juice was offered (juice days) and not offered (non-juice days) with the reimbursable school meal.

Factors Influencing Dietary Intake Frequencies and Nutritional Risk among Community-Residing Older Adults.

Older adult (OA) dietary practices may be placing them at nutritional risk. This cross-sectional study examined the dietary intake frequencies (DIF) and nutritional risk (NR) using the Dietary Screeni...

Juice Clarification with Pectinase Reduces Yeast Assimilable Nitrogen in Apple Juice without Affecting the Polyphenol Composition in Cider.

The term "cider" refers to the fermented beverage produced from apples. The rapid growth in the cider industry coupled with the prominence of traditional, or craft, approaches emphasizes the need for ...

White grape juice increases high-density lipoprotein cholesterol levels and reduces body mass index and abdominal and waist circumference in women.

Grape juice is a drink that is rich in phenolic compounds, which are important natural antioxidants that reduce the incidence of diseases linked to oxidative stress including cardiovascular disease. S...

Soil threshold values for cadmium based on paired soil-vegetable content analyses of greenhouse vegetable production systems in China: Implications for safe food production.

Greenhouse vegetable production (GVP) is the major type of vegetable production in China. However, dietary exposure of heavy metals through vegetable consumption has been identified as a potential ris...

Medical and Biotech [MESH] Definitions

The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

A treatment schedule in which the total dose of radiation is divided into large doses.

Proteins which are present in or isolated from vegetables or vegetable products used as food. The concept is distinguished from PLANT PROTEINS which refers to non-dietary proteins from plants.

Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production.

The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)

More From BioPortfolio on "The Juice Study: Sensitivity of Skin Carotenoid Status to Detect Change in Intake"

Quick Search


Relevant Topics

Acne Dermatology Eczema Psoriasis Wound Care Dermatology is the medical specialty concerned with the diagnosis and treatment of skin disorders (Oxford Medical Dictionary). As well as studying how the skin works, dermatology covers...

Wound management
Anything that breaks the skin is a wound because when the skin is broken, there's a risk of germs getting into the body and causing an infection. Follow and track Wound Care News on BioPortfolio: Wound Car...

Obesity is the condition in which excess fat has accumulated in the body (mostly in subcutaneous tissues). clinical obesity is considered to be present when a person has a BMI of over 30 (Oxford Dictionary of Medicine). It is becoming increasing common i...

Searches Linking to this Trial