The Impact of Contact Lens Coefficient of Friction (CoF) on the Development of Lid Wiper Epitheliopathy (LWE)

2017-07-07 07:08:22 | BioPortfolio


This study examines the development of Lid Wiper Epitheliopathy (LWE) in individuals fit with contact lenses having difference coefficients of friction (CoF)


The primary study objectives are to determine the amount of Lid Wiper Epitheliopathy (LWE) induced in subjects after contact lens fitting that do not have LWE at study enrollment. Subjects in the trial will be fit in 2 contact lenses with different coefficients of friction (CoF). One eye will be fit in a contact lens with a low coefficient of friction (Acuvue Oasys®, Johnson & Johnson Vision, Jacksonville FL) while the contralateral eye will be fit in a contact lens with a high CoF (Air Optix® Night & Day® Aqua, Ft. Worth, TX), as reported in the scientific literature. The eye receiving each lens will be assigned randomly. The presence of LWE will be assessed at 2 different time points, approximately 2 hours after contact lens fitting and approximately after 7 days of contact lens wear.

Study Design


Lid Wiper Epitheliopathy


Acuvue Oasys, Air Optix Night & Day Aqua


The Ocular Surface Institute, The University of Houston College of Optometry
United States


Not yet recruiting


University of Houston

Results (where available)

View Results


Published on BioPortfolio: 2017-07-07T07:08:22-0400

Clinical Trials [224 Associated Clinical Trials listed on BioPortfolio]

Lens Metrology Study

The purpose of this study is to evaluate changes in contact lens geometry after lens wear

Lid Wiper Epitheliopathy Trial

The purpose of this study is to evaluate the effect of contact lens lubricity on lid wiper epitheliopathy (LWE) in symptomatic contact lens wearers. LWE is defined as an alteration of that...

Comparative Performance of PureVision, Acuvue Oasys and O2Optix

The objective of this study is to evaluate the performance of the PureVision Contact Lens compared to Acuvue Oasys Contact lens and O2Optix Contact lens when worn on a daily wear basis.

Clinical Evaluation of ACUVUE® OASYS® 1-Day and ACUVUE® OASYS®

The purpose of this study is to evaluate the performance of two commercially-available silicone hydrogel contact lenses in normal and low humidity environments after at least 7 days of wea...

ACUVUE® OASYS With Transitions™ Light Intelligent Technology™ Clinical Performance Registry

This registry study is a one-year, one-visit, observational, prospective, open-label, two-arm, multi-center, multi-national, post-market study of approximately 300 patients who have recent...

PubMed Articles [337 Associated PubMed Articles listed on BioPortfolio]

OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy.

To describe retinal and choroidal findings in different stages of acute posterior multifocal placoid pigment epitheliopathy (APMPPE).

Estimation of monthly surface air temperatures from MODIS LST time series data: application to the deserts in the Sultanate of Oman.

Air temperature records in remote deserts and inaccessible mountainous regions rely upon data acquired from the nearest meteorological stations, which could be at tens of kilometers apart. The present...

Carbon compositional analysis of hydrogel contact lenses by solid-state NMR spectroscopy.

Contact lenses are worn by over 140 million people each year and tremendous research and development efforts contribute to the identification and selection of hydrogel components and production protoc...

Night work during pregnancy and preterm birth-A large register-based cohort study.

Melatonin stimulates the production of progesterone, which is essential for the maintenance of pregnancy. Since melatonin in blood is reduced due to work under illuminated conditions during night work...

Drinking to go out or going out to drink? A longitudinal study of alcohol in night-time entertainment districts.

Recent research has highlighted the growing trend of alcohol preloading before a night out. We wished to look at people's motivations for preloading, their estimation for drinking during the night, an...

Medical and Biotech [MESH] Definitions

Failure or imperfection of vision at night or in dim light, with good vision only on bright days. (Dorland, 27th ed)

A species in the family AOTIDAE, inhabiting the forested regions of Central and South America (from Panama to the Amazon). Vocalizations occur primarily at night when they are active, thus they are also known as Northern night monkeys.

Institutional night care of patients.

Involuntary discharge of URINE during sleep at night after expected age of completed development of urinary control.

Frequent URINATION at night that interrupts sleep. It is often associated with outflow obstruction, DIABETES MELLITUS, or bladder inflammation (CYSTITIS).

More From BioPortfolio on "The Impact of Contact Lens Coefficient of Friction (CoF) on the Development of Lid Wiper Epitheliopathy (LWE)"

Quick Search

Relevant Topic

The Top 100 Pharmaceutical Companies
Top 10 biotech and pharmaceutical companies worldwide based on market value in 2015 2015 ranking of the global top 10 biotech and pharmaceutical companies based on revenue (in billion U.S. dollars) Johnson & Johnson, U.S. 74...

Searches Linking to this Trial