Topics

Early Detection and Treatment of Respiratory Sleep Disorders in Children With Down Syndrome

2017-07-11 09:19:51 | BioPortfolio

Summary

Interventional, comparative, open label, single-center study to demonstrate that an early (from 6 months of age) and systematic (every 6 months) screening of Obstructive Sleep Apnea (OSA) by polysomnography (PSG) in children with Down Syndrome during the first 3 years of life is associated with an improved neurocognitive development at the age of 3 years.

Study Design

Conditions

Obstructive Sleep Apnea in Childen With Down Syndrome

Intervention

Polysomnography (PSG)

Location

Institut Jérome Lejeune
Paris
France
75015

Status

Recruiting

Source

Institut Jerome Lejeune

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-07-11T09:19:51-0400

Clinical Trials [3519 Associated Clinical Trials listed on BioPortfolio]

Cardiovascular Variability and Heart Rate Response Associated With Obstructive Sleep Apnea

Obstructive sleep apnea is often associated with microarousals and a stimulation of the sympathetic nervous system. The knowledge of this autonomic activation may help understanding the in...

Sleep Apnea: Mechanism and Cerebrovascular Consequences

This study will determine the effect of ventilatory stimulation on obstructive sleep apnea in selected patients with stroke. We will select a subset of patients with stroke in the prior 3...

Polysomnography and Heart Rate Indexes in Obstructive Sleep Apnea

The purpose of this study is to evaluate the diagnostic accuracy of polysomnography indexes for diagnosis of sleep apnea in human subjects obstructive sleep apnea (OSA). This includes eval...

Belun Ring Validation Study for Assessment of Obstructive Sleep Apnea

This study aims to determine the overall accuracy, sensitivity, and specificity of the Belun Ring device in evaluating obstructive sleep apnea by comparing the device to the attended overn...

Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese

This study evaluates the effectiveness of intraoral appliance in the treatment of obstructive sleep Apnea Syndrome in class III obese in comparison to an adjustable silicone appliance. Bot...

PubMed Articles [6640 Associated PubMed Articles listed on BioPortfolio]

Is there an association between sleep bruxism and obstructive sleep apnea syndrome? A systematic review.

To elucidate current knowledge on the potential association and causality between sleep bruxism (SB) and obstructive sleep apnea (OSA) using full-night polysomnography.

SIESTA - Home sleep study with BresoDx for obstructive sleep apnea: a randomized controlled trial.

The objectives of this study were to evaluate (1) the accuracy of the clinical diagnosis of obstructive sleep apnea (OSA) informed by the home sleep study with a Type 4 portable monitor BresoDx® vers...

Obstructive sleep apnea screening by heart rate variability-based apnea/normal respiration discriminant model.

Obstructive sleep apnea (OSA) is a common sleep disorder; however, most patients are undiagnosed and untreated because it is difficult for patients themselves to notice OSA in daily living. Polysomnog...

The impact of intranasal fluticasone on patients with obstructive sleep apnea: a prospective study.

Obstructive sleep apnea is the most common type of sleep apnea, which is caused by complete or partial obstructions of the upper airway. Nasal obstruction is also considered as one of the independent ...

Analysis of sleep structure and related factors in children with severe obstructive sleep apnea-hypopnea syndrome.

To investigate the sleep structure and related factors in children with severe obstructive sleep apnea-hypopnea syndrome(OSAHS). We summarized the characteristics of 250 children withsevere OSAHS dia...

Medical and Biotech [MESH] Definitions

A condition associated with multiple episodes of sleep apnea which are distinguished from obstructive sleep apnea (SLEEP APNEA, OBSTRUCTIVE) by the complete cessation of efforts to breathe. This disorder is associated with dysfunction of central nervous system centers that regulate respiration. This condition may be idiopathic (primary) or associated with lower brain stem lesions; chronic obstructive pulmonary disease (LUNG DISEASES, OBSTRUCTIVE); HEART FAILURE, CONGESTIVE; medication effect; and other conditions. Sleep maintenance is impaired, resulting in daytime hypersomnolence. Primary central sleep apnea is frequently associated with obstructive sleep apnea. When both forms are present the condition is referred to as mixed sleep apnea (see SLEEP APNEA SYNDROMES). (Adams et al., Principles of Neurology, 6th ed, p395; Neurol Clin 1996;14(3):611-28)

Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.

HYPOVENTILATION syndrome in very obese persons with excessive ADIPOSE TISSUE around the ABDOMEN and DIAPHRAGM. It is characterized by diminished to absent ventilatory chemoresponsiveness; chronic HYPOXIA; HYPERCAPNIA; POLYCYTHEMIA; and long periods of sleep during day and night (HYPERSOMNOLENCE). It is a condition often related to OBSTRUCTIVE SLEEP APNEA but can occur separately.

Posterior displacement of the TONGUE toward the PHARYNX. It is often a feature in syndromes such as in PIERRE ROBIN SYNDROME and DOWN SYNDROME and associated with AIRWAY OBSTRUCTION during sleep (OBSTRUCTIVE SLEEP APNEAS).

The time it takes to reach REM SLEEP. It is typically measured by POLYSOMNOGRAPHY or EEG as a part of various sleep pattern tests (e.g., multiple sleep latency test).

More From BioPortfolio on "Early Detection and Treatment of Respiratory Sleep Disorders in Children With Down Syndrome"

Quick Search

Relevant Topics

Sleep Disorders
Sleep disorders disrupt sleep during the night, or cause sleepiness during the day, caused by physiological or psychological factors. The common ones include snoring and sleep apnea, insomnia, parasomnias, sleep paralysis, restless legs syndrome, circa...

Pediatrics
Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...


Searches Linking to this Trial