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Microwave Ablation in Mild Axillary Hidradenitis Suppurativa

2017-08-04 13:53:29 | BioPortfolio

Summary

With microwave ablation (MWA), using the heat generated from electromagnetic waves in the microwave energy spectrum, hair follicles and apocrine glands in the (hypo)dermis are ablated through thermolysis. MWA was recently approved for the treatment of axillary hyperhidrosis (miraDry) and removal of axillary hair (miraSmooth). By permanent removal of hairs and sweat glands, we hypothesize a beneficial and long-term sustainable preventive effect of MWA in HS patients.

Description

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease of the hair follicle, and is predominantly located in the axillary, inguinal and anogenital regions. Current treatment options for HS include systemic oral antibiotics, anti-TNFα, and surgery, which are used to treat the consequences rather than treating the primary pathogenesis of HS. With microwave ablation (MWA), using the heat generated from electromagnetic waves in the microwave energy spectrum, hair follicles, eccrine and apocrine glands in the (hypo)dermis are ablated through thermolysis. MWA was recently approved for the treatment of axillary hyperhidrosis (miraDry) and removal of axillary hair (miraSmooth). By permanent removal of hairs and sweat glands, we hypothesize a beneficial and long-term sustainable preventive effect of MWA in HS patients.

Study Design

Conditions

Hidradenitis Suppurativa

Intervention

Microwave ablation

Location

Erasmus University Medical Center
Rotterdam
Netherlands

Status

Not yet recruiting

Source

Erasmus Medical Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-08-04T13:53:29-0400

Clinical Trials [725 Associated Clinical Trials listed on BioPortfolio]

Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis Suppurativa

The trial enrolls patients with moderate to severe Hidradenitis Suppurativa (HS). The primary goal of the trial is to evaluate the safety and tolerability of IFX-1 administered over 8 week...

Post-Marketing Surveillance of Adalimumab in Korean Hidradenitis Suppurativa Subjects

The objective of this study is to evaluate the safety profile of Adalimumab for Hidradenitis Suppurativa (HS) participants in normal medical practice.

A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa.

Purpose: To evaluate the effectiveness of intralesional triamcinolone for the treatment of hidradenitis suppurativa Participants: Patients diagnosed with Hidradenitis Suppurativa that hav...

Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa

This study will investigate how well adalimumab works in people with hidradenitis suppurativa (HS) in the short and long term.

Single Center Study of Apremilast for the Treatment of Hidradenitis Suppurativa

The primary objective of this study is to evaluate the safety and efficacy of Apremilast in subjects with moderate hidradenitis suppurativa (HS).

PubMed Articles [1187 Associated PubMed Articles listed on BioPortfolio]

Aggravation of mild axillary hidradenitis suppurativa by microwave ablation: results of a randomized intra-patient controlled trial.

Reliability of the hidradenitis suppurativa clinical response (HiSCR) in the assessment of patients with hidradenitis suppurativa.

Hidradenitis suppurativa clinical response (HiSCR) is a validated clinical end point for measuring response to treatment in patients with hidradenitis suppurativa (HS). Previous studies have reported ...

Hidradenitis Suppurativa-Like Condition Occurring After Microwave Sweat Gland Ablation.

Impact of Hidradenitis Suppurativa on Work Loss, Indirect Costs and Income.

Hidradenitis suppurativa (HS), a chronic cutaneous disease, can negatively affect work life.

A Retrospective Cohort Study on Patients with Hidradenitis Suppurativa.

Hidradenitis suppurativa (HS) is one of the most distressing conditions observed in dermatology and has a substantial negative effect on the quality of life of affected persons.

Medical and Biotech [MESH] Definitions

Removal of tissue by vaporization, abrasion, or destruction. Methods used include heating tissue by hot liquids or microwave thermal heating, freezing (CRYOABLATION), chemical ablation, and photoablation with LASERS.

A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.

The inflammation of a sweat gland (usually of the apocrine type). The condition can be idiopathic or occur as a result of or in association with another underlying condition. Neutrophilic eccrine hidradenitis is a relatively rare variant that has been reported in patients undergoing chemotherapy, usually for non-Hodgkin lymphomas or leukemic conditions.

That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.

Procedures used for the targeted destruction of the mucous membrane lining of the uterine cavity.

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