the Effects of Cerebral Collateral Circulation on the Outcome of Leukoaraiosis in High-risk Population

2017-08-13 15:49:43 | BioPortfolio


This study observed the relationship between cerebral collateral circulation and the prognosis of leukoaraiosis in high-risk population. Cerebral collateral circulation and leukoaraiosis levels will be evaluated and followed up by magnetic resonance examination. The participants' clinical performance caused by leukoaraiosis will be assessed by a series of scales.


1. Case collection information is sent daily to clinical trial supervisors.

2. The clinical trial team meets once a week to monitor the quality of clinical trials.

3. The severity of the leukoaraiosis will be evaluated by a scale. The patients whose score is more than 2 will take additional magnetic resonance examination including magnetic resonance angiography (MRA) and arterial spin labeling (ASL). And their cognitive ability will be evaluated by a series of scales including Mini-Mental State Examination (MMSE) and Montreal cognitive assessment (MoCA) and gait by the short physical performance battery (SPPB).

The blood sample will be taken for biochemical detection and hair and nail samples for trace element detection.

4. Data were analyzed by regression analysis.

Study Design




Not yet recruiting


Shanghai Zhongshan Hospital

Results (where available)

View Results


Published on BioPortfolio: 2017-08-13T15:49:43-0400

Clinical Trials [0 Results]


PubMed Articles [7 Associated PubMed Articles listed on BioPortfolio]

Disconnections of Cortico-Subcortical Pathways Related to Cognitive Impairment in Patients with Leukoaraiosis: A Preliminary Diffusion Tensor Imaging Study.

We aimed to explore the relation between the microstructural integrity of white matter using the technique of diffusion tensor imaging (DTI) and changes of cognition in leukoaraiosis (LA).

Relationship between Carotid Computed Tomography Dual-Energy and Brain Leukoaraiosis.

The purpose of this study was to assess if there is a correlation between the carotid computed tomography (CT) Hounsfield unit (HU)-based plaque attenuation values measured using dual-energy CT (DECT)...

Multiple Silent Brain Infarcts Are Associated with Severer Stroke in Patients with First-Ever Ischemic Stroke without Advanced Leukoaraiosis.

Silent brain infarct (SBI) is associated with symptomatic stroke, but the association between SBI and acute ischemic stroke severity is uncertain. We aimed at investigating the association between SBI...

Analysis of risk factors in patients with leukoaraiosis.

To investigate the risk factors for leukoaraiosis (LA) and the correlation between risk factors and LA.The study comprised 92 patients with diagnoses of LA (LA group) and 56 non-LA individuals (contro...

Correlation between prefrontal-striatal pathway impairment and cognitive impairment in patients with leukoaraiosis.

Our study aimed to investigate the changes of white matter microstructure of cortico-subcortical pathways using diffusion tensor imaging (DTI), and to explore the relationship between abnormal paramet...

Medical and Biotech [MESH] Definitions

Non-specific white matter changes in the BRAIN, often seen after age 65. Changes include loss of AXONS; MYELIN pallor, GLIOSIS, loss of ependymal cells, and enlarged perivascular spaces. Leukoaraiosis is a risk factor for DEMENTIA and CEREBROVASCULAR DISORDERS.

Pathological processes or diseases where cerebral MICROVESSELS show abnormalities. They are often associated with aging, hypertension and risk factors for lacunar infarcts (see LACUNAR INFARCTION); LEUKOARAIOSIS; and CEREBRAL HEMORRHAGE.

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