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The Expression of CD 95, CD20, CD34 and CD44 in Acute Lymphoblastic Leukemia

2017-08-15 16:38:21 | BioPortfolio

Summary

Acute lymphoblastic leukemia , also known as acute lymphocytic leukemia, characterized by the overproduction and accumulation of cancerous, immature white blood cells, known as lymphoblasts, causing damage and death by inhibiting the production of normal cells (such as red and white blood cells and platelets) in the bone marrow and by spreading (infiltrating) to other organs. Acute lymphoblastic leukemia is most common in childhood, with a peak incidence at 2-5 years of age and another peak in old age.

Description

In recent years, new pieces of information obtained through immunophenotyping, cytogenetics and genomic profiling. Chemotherapy resistance have contributed to a better understanding of the pathology of this complex disorder and to recognition of subgroups of patients who respond differently to therapy.The possible impact of the expression of various markers has been studied in Acute lymphoblastic leukemia.CD95 death receptor, CD20 (B-lineage) in addition to CD34 and CD44 non-lineage-associated differentiation markers are surface molecules that have been reported to have a relationship with some clinical and laboratory features of Acute lymphoblastic leukemia patients at presentation, but the results are conflicting.CD95 , a member of the tumor necrosis factor receptor super family is a transmembrane protein that in a caspase-dependent pathway can induce cell death.CD44, a cell surface proteoglycan is widely distributed in different cells and can mediate lymphocyte adhesion to the vascular endothelium and extracellular matrix proteins, Previous studies showed that stimulation of CD44 reduced Fas expression and Fas-mediated apoptosis.CD34 is a transmembrane phosphoglycoprotein, first identified on hematopoietic stem and progenitor cells,functions as a cell-cell adhesion factor. Cd 34 may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells.CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells,functions to enable optimal B-cell immune response, specifically against T-independent antigens.CD 20 is suspected that it acts as a calcium channel in the cell membrane.It has been shown that CD20 plays a role in the microenvironmental interactions of B cells.

Several studies have been performed to examine the potential impact of these molecules in predicting treatment outcome. However, to the best of our knowledge, the value of the expression of these molecules in Egyptian patients with acute lymhoblastic leukemia is unclear.

Study Design

Conditions

Acute Lymphoblastic Leukemia

Intervention

Flow cytometric analysis

Location

Assiut University
Assiut
Egypt

Status

Not yet recruiting

Source

Assiut University

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-08-15T16:38:21-0400

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PubMed Articles [21967 Associated PubMed Articles listed on BioPortfolio]

Flow Cytometric False Myeloperoxidase-positive Childhood B-Lineage Acute Lymphoblastic Leukemia.

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B Lymphoblastic Leukemia Minimal Residual Disease Assessment by Flow Cytometric Analysis.

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To explore the value of flow cytometric (FCM) analysis of cerebrospinal fluid (CSF) in the diagnosis of central nervous system involvement in adult patients with acute lymphoblastic leukemia (ALL) dur...

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Treating Adult Acute Lymphoblastic Leukemia in Brazil-Increased Early Mortality Using a German Multicenter Acute Lymphoblastic Leukemia-based regimen.

Acute lymphoblastic leukemia (ALL) in adults is an invariably aggressive and rare disease. Its treatment is based on the use of multidrug regimens, which have been improved since the 1970s. Few publis...

Medical and Biotech [MESH] Definitions

A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors.

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)

Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

A leukemia/lymphoma found predominately in children and adolescents and characterized by a high number of lymphoblasts and solid tumor lesions. Frequent sites involve LYMPH NODES, skin, and bones. It most commonly presents as leukemia.

A rare acute myeloid leukemia characterized by abnormal EOSINOPHILS in the bone marrow.

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