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The aim is to study the microenvironment of chronic biofilm infection in diabetic wounds which shows deregulated immune cells responses and biofilm interaction resulting in delayed/impaired/non wound healing. We seek to understand immune evasion strategy of biofilms and study mechanisms which biofilm modify macrophages phenotype and functions in such wounds
1. Determine if functionally active macrophage isolated from biofilm-infected diabetic wounds show extra cellular matrix degrading phenotype causing wound collagen degradation
2. Understand by investigating whether increased presence of ECM degrading wound macrophage phenotypes in biofilm infected human diabetic wounds are associated with reduced wound collagen levels and increased wound recurrence End goal will be to understand the mechanism in which biofilm modulates the wound macrophage phenotype and function
Finger prick test for HbA1c measurement, Punch Biopsy, Vac Sponge Collection, Ankle Brachial Index
The Ohio State University Hospital East
Ohio State University
Published on BioPortfolio: 2017-09-05T21:38:21-0400
The purpose of this study was to identify accuracy rates of 2mm punch biopsy technique in diagnosing periocular malignancy.
The present European survey seeks to assess quality of life and satisfaction with treatment in people with T2DM and to appreciate disease and treatment variables including hypoglycaemia an...
The purpose of this study is to investigate stress response pathways in tissues and melanocytes from patients with vitiligo. Investigators are collecting evidence of UPR and stress respons...
The purpose of this study is to evaluate the potential correlation of the results of allergen-specific skin prick tests (SPT) to that of allergen-specific microarray determination (microas...
The purpose of this study is to test whether bar coded surgical sponges can significantly increase the safety of operations, specifically by (1) reducing discrepancies and miscounts, (2) r...
Implementation of point-of-care HbA1c devices in the preoperative outpatient clinic might facilitate the early diagnosis of glycemic disturbances in overweight or obese patients undergoing surgery, bu...
Dried Blood Spot (DBS) sampling is a promising method for collection of microliter blood samples. However, hematocrit-related bias in combination with sub-punch analysis can result in inaccurate quant...
This study aimed to evaluate the performance of HbA1c measurement systems quantitatively with sigma metric and promote the quality improvement.
Background We conducted a systematic review and meta-analysis to establish the overall accuracy of glycated hemoglobin (HbA1c) in the diagnosis of gestational diabetes mellitus (GDM) diagnosis. Method...
A diagnostic test in which vitamin B12 is tagged with radioactive cobalt, taken orally, and gastrointestinal absorption is determined via measurement of the amount of radioactivity in a 24-hour urine collection.
Sterile, gelatin-base surgical sponge applied topically as an adjunct to hemostasis when the control of bleeding by conventional procedures is ineffective to reduce capillary ooze or is impractical. (From AMA Drug Evaluations Annual, 1994, p797)
Conducting a biopsy procedure with the aid of a MEDICAL IMAGING modality.
Force exerted when using the index finger and the thumb. It is a test for determining maximum voluntary contraction force.
Disease involving the ULNAR NERVE from its origin in the BRACHIAL PLEXUS to its termination in the hand. Clinical manifestations may include PARESIS or PARALYSIS of wrist flexion, finger flexion, thumb adduction, finger abduction, and finger adduction. Sensation over the medial palm, fifth finger, and ulnar aspect of the ring finger may also be impaired. Common sites of injury include the AXILLA, cubital tunnel at the ELBOW, and Guyon's canal at the wrist. (From Joynt, Clinical Neurology, 1995, Ch51 pp43-5)
Antiretroviral Therapy Clostridium Difficile Ebola HIV & AIDS Infectious Diseases Influenza Malaria Measles Sepsis Swine Flu Tropical Medicine Tuberculosis Infectious diseases are caused by pathogenic...
Diabetes is a lifelong condition that causes a person's blood sugar level to become too high. The two main types of diabetes are: type 1 diabetes type 2 diabetes In the UK, diabetes affects approximately 2.9 million people. There are a...
Anything that breaks the skin is a wound because when the skin is broken, there's a risk of germs getting into the body and causing an infection. Follow and track Wound Care News on BioPortfolio: Wound Car...