Topics

The University of Hong Kong Neurocognitive Disorder Cohort

2017-09-07 23:08:21 | BioPortfolio

Summary

The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment.

Description

The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment, and in particular the biomarkers that predict cognitive and functional decline.

Comprehensive profiling of each subject is performed through a multi-domain assessment protocol including detailed demographics, lifestyle factors, neuropsychological battery, mood, MRI, genetics, blood biomarkers, and other patient-centred parameters including level of disability, quality of life and societal engagement. Ongoing annual follow up captures the essential clinical events and changes in neurocognitive function (conversion to MCI or dementia), mood, level of disability and quality of life; as well as repeat blood tests.

The HKU NCD Cohort is the first-ever Asian dementia cohort to be formally included into the Dementia Platforms UK, achieving an international collaborative status with other UK-based cohorts. The study neuropsychological battery is aligned with the NACC UDS3 battery.

Study Design

Conditions

Neurocognitive Disorder

Intervention

Neurocognitive battery, MRI, Blood tests, EEG with event-related potential (ERP), Amyloid PET CT

Location

Department of Medicine, Queen Mary Hospital, The University of Hong Kong
Hong Kong
Hong Kong

Status

Recruiting

Source

The University of Hong Kong

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-09-07T23:08:21-0400

Clinical Trials [2598 Associated Clinical Trials listed on BioPortfolio]

Neurocognitive Outcome in Children Who Suffered From Idiopathic Increased Intracranial Hypertension (IIH)

15 patients, Ages 8-17 who were diagnosed in the recent years with Idiopathic increased intracarnial hypertension (IIH) went through a battery of neurocognitive tests to establish whether ...

Evaluation of an Online, Remote Cognitive Battery for Use in Cancer Survivorship

The purpose of this study is to measure changes in cognitive (mental) function in cancer survivors using a brief, reliable, game-like set of tests that can be completed outside the clinic,...

Function-Related Tests for Subjects With Stiff Shoulders: Reliability and Validity

Background: Shoulder-related dysfunction (SD) is a common health problem in various patient populations. SD can affect an individual's ability to function independently, consequently decr...

Event-Related Potential (ERP) Biomarkers in Subjects With Schizophrenia and Healthy Volunteer Subjects

This is an observational, non-interventional study that will recruit Healthy Volunteers (HV) and subjects with clinically confirmed Schizophrenia (SZ). The purpose of this study is to esta...

Comparison Study of the Different Abbreviated Versions of the Geriatric Depression Scale

This multicenter study conducted in several Portuguese institutions aims to compare the screening ability of the several Geriatric Depression Scale (GDS) validated versions for the Portugu...

PubMed Articles [29600 Associated PubMed Articles listed on BioPortfolio]

N400 event-related brain potential as an index of real-world and neurocognitive function in patients at clinical high risk for schizophrenia.

The N400 event-related potential is a neurophysiological index of cognitive processing of real-world knowledge. In healthy populations, N400 amplitude is smaller in response to stimuli that are more r...

High occurrence of sleep problems in survivors of a childhood brain tumor with neurocognitive complaints: The association with psychosocial and behavioral executive functioning.

Survivors of childhood brain tumors are prone to sleep and neurocognitive problems. Effective interventions to improve neurocognitive functioning are largely lacking. In general, sleep problems are ne...

Neurocognitive challenged hops reduced functional performance relative to traditional hop testing.

Determine the relationship between four foundational single-leg hop tests and respective neurocognitive single-leg hop tests.

Portable diagnosis of sleep apnea with the validation of individual event detection.

To develop an algorithm for improving apnea hypopnea index (AHI) estimation which includes event by event validation and event duration estimation. The algorithm uses breathing sounds, respiratory rel...

A neural-vascular complex of age-related changes in the human brain: Anatomy, physiology, and implications for neurocognitive aging.

Theories of neurocognitive aging rely heavily on functional magnetic resonance imaging (fMRI) to test hypotheses regarding the brain basis of age-differences in cognition. This technique is based on t...

Medical and Biotech [MESH] Definitions

A late-appearing component of the event-related potential. P300 stands for a positive deflection in the event-related voltage potential at 300 millisecond poststimulus. Its amplitude increases with unpredictable, unlikely, or highly significant stimuli and thereby constitutes an index of mental activity. (From Campbell, Psychiatric Dictionary, 6th ed)

A series of tests designed to assess neuropsychological function. The battery is used to diagnose specific cerebral dysfunction and also to determine lateralization.

Tests designed to assess various aspects of neurocognitive function and/or dementia.

Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.

Tests or bioassays that measure the skin sensitization potential of various chemicals.

More From BioPortfolio on "The University of Hong Kong Neurocognitive Disorder Cohort"

Quick Search

Relevant Topic

Radiology
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...


Searches Linking to this Trial