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Effect of Probiotics on Nasopharyngeal Microbiome of Children With Otitis Media With Effusion

2017-09-12 00:08:22 | BioPortfolio

Summary

The aim of this study is to investigate whether the microbiota in the upper respiratory tract (nasopharynx, adenoids and middle ear fluid) of otitis media with effusion (OME) patients is changed after 4 weeks of probiotic product intake. Therefore, bacterial DNA from swabs, fluid and tissue will be isolated via commercially available DNA extraction kits, followed by Illumina MiSeq sequencing in order to identify the bacterial species present in these samples. Furthermore, the concentration of specific pathogens will be monitored via qPCR.

Study Design

Conditions

Otitis Media With Effusion

Intervention

Probactiol Mini

Location

Antwerp University Hospital
Edegem
Antwerp
Belgium
2650

Status

Recruiting

Source

University Hospital, Antwerp

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-09-12T00:08:22-0400

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Medical and Biotech [MESH] Definitions

Inflammation of the middle ear with a clear pale yellow-colored transudate.

Inflammation of the ear, which may be marked by pain (EARACHE), fever, HEARING DISORDERS, and VERTIGO. Inflammation of the external ear is OTITIS EXTERNA; of the middle ear, OTITIS MEDIA; of the inner ear, LABYRINTHITIS.

Inflammation of the middle ear with purulent discharge.

Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.

Inflammation of the honeycomb-like MASTOID BONE in the skull just behind the ear. It is usually a complication of OTITIS MEDIA.

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