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Fatty Acid Biomarkers of Carbohydrate Intake

2017-09-28 04:38:22 | BioPortfolio

Summary

The overall aim is to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality.

Description

In this isocaloric clinical cross-over trial, we aim to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality. We intend to evaluate if changes in carbohydrate quantity and quality (including sugar) influence circulating even-chain saturated fatty acids or if fatty acid-derived indices of desaturation and de novo lipogenesis are more sensitive biomarkers of carbohydrate intake. By performing untargeted lipidomic analyses, we aim to search for novel lipid biomarkers of carbohydrate quantity and quality. We also want to evaluate the influence of moderate alterations of carbohydrate and sugar intake on lipoproteins, insulin sensitivity, inflammatory proteins.

Study Design

Conditions

Dyslipidemias

Intervention

Low carbohydrate diet, High carbohydrate, high sugar diet, High carbohydrate, low sugar diet

Location

Uppsala univeristy hospital
Uppsala
Sweden
75185

Status

Recruiting

Source

Uppsala University

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-09-28T04:38:22-0400

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Medical and Biotech [MESH] Definitions

A diet that consists mainly of foods with a high content of protein and limited amounts of CARBOHYDRATES.

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A diet that includes foods with a high protein content.

A diet rich in DIETARY CARBOHYDRATES.

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