Advertisement

Topics

Low Dose Exposure to Oxidized R-limonene - A Repeated Open Application Test (ROAT) Study

2017-10-23 20:44:13 | BioPortfolio

Summary

This study evaluates the clinical and molecular effect of daily exposure to low doses of the fragrance contact allergen oxidized R-limonene. Three groups of participants are included: 1) Patients with a previous positive patch test to oxidized R-Limonene, 2) patients with a previous doubtful patch test to oxidized R-limonene and 3) healthy controls with no contact allergy to oxidized R-limonene

Study Design

Conditions

Allergic Contact Dermatitis Due to Cosmetics

Intervention

ROAT with oxidized R-limonene at 1%, 0.3% and 0.1%, ROAT with oxidized R-limonene at 1%

Location

Department of Dermatology and Allergy, Gentofte University Hospital
Hellerup
DK
Denmark
2900

Status

Enrolling by invitation

Source

Herlev and Gentofte Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-10-23T20:44:13-0400

Clinical Trials [40 Associated Clinical Trials listed on BioPortfolio]

Limonene Study in Women With Breast Cancer

Limonene is a major component in the essential oils of citrus fruits. It has demonstrated promising breast cancer preventive and therapeutic effects in preclinical model systems. This ear...

Effect of Ezetimibe on Oxidized Low-density Lipoprotein (LDL) Cholesterol

Randomized study. Patients with coronary artery disease equivalent will be randomized to receive atorvastatin 40 mg/day + placebo vs. atorvastatin 40 mg/day + ezetimibe 40 mg/day. Oxidized...

Hämeenlinna Metabolic Syndrome Research Program: Oxidized LDL and Arterial Elasticity in Metabolic Syndrome and Controls (HMS-01)

Mechanisms that link metabolic syndrome to atherosclerosis are incompletely understood. As a part of Hämeenlinna Metabolic Syndrome Research Program (HMS), 40 men with metabolic syndrome...

Oxidized Glutathione (NOV-002), Doxorubicin, Cyclophosphamide, and Docetaxel in Treating Women With Newly Diagnosed Stage IIB, or Stage IIIC Breast Cancer

RATIONALE: Oxidized glutathione (NOV-002) may stimulate the immune system in different ways and stop tumor cells from growing. Drugs used in chemotherapy, such as doxorubicin, cyclophospha...

Bioavailability of Ubiquinone and Ubiquinol in Older Adults

Coenzyme Q10 (or CoQ10) is a marketed supplement in US even though it can be synthesized in the body via complicated biochemical pathways. It exists in both reduced and oxidized states, na...

PubMed Articles [590 Associated PubMed Articles listed on BioPortfolio]

Non-mix fragrances are top sensitizers in consecutive dermatitis patients - a cross-sectional study of the 26 EU-labelled fragrance allergens.

For cosmetics, it is mandatory to label 26 fragrance substances, including all constituents of fragrance mix I (FM I) and fragrance mix II (FM II). Earlier reports have not included oxidized R-limonen...

Real-Time Evolution of Zika Virus Disease Outbreak, Roatán, Honduras.

A Zika virus disease outbreak occurred in Roatán, Honduras, during September 2015-July 2016. Blood samples and clinical information were obtained from 183 patients given a clinical diagnosis of suspe...

Limonene protects osteoblasts against methylglyoxal-derived adduct formation by regulating glyoxalase, oxidative stress, and mitochondrial function.

Methylglyoxal (MG) is a potent protein glycating agent and an important precursor of advanced glycation end products, which are involved in the pathogenesis of diabetic osteopathy. In this study, we i...

Effects of Foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing.

We investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the ...

A Role for 2-Methyl Pyrrole in the Browning of 4-Oxopentanal and Limonene Secondary Organic Aerosol.

Reactions of ammonia or ammonium sulfate (AS) with carbonyls in secondary organic aerosol (SOA) produced from limonene are known to form brown carbon (BrC) with a distinctive absorption band at 505 nm...

Medical and Biotech [MESH] Definitions

Members of the P-450 enzyme family that take part in the hydroxylation of limonene.

A group of cell-surface receptors for oxidatively modified LOW-DENSITY LIPOPROTEINS. The group includes certain SCAVENGER RECEPTORS that contribute to the pathogenesis of ATHEROSCLEROSIS by uptake of oxidized LDL.

A colorless compound formed in the intestines by the reduction of bilirubin. Some is excreted in the feces where it is oxidized to urobilin. Some is reabsorbed and re-excreted in the bile as bilirubin. At times, it is re-excreted in the urine, where it may be later oxidized to urobilin.

A family of thioltransferases that contain two active site CYSTEINE residues, which either form a disulfide (oxidized form) or a dithiol (reduced form). They function as an electron carrier in the GLUTHIONE-dependent synthesis of deoxyribonucleotides by RIBONUCLEOTIDE REDUCTASES and may play a role in the deglutathionylation of protein thiols. The oxidized forms of glutaredoxins are directly reduced by the GLUTATHIONE.

Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.

More From BioPortfolio on "Low Dose Exposure to Oxidized R-limonene - A Repeated Open Application Test (ROAT) Study"

Quick Search
Advertisement
 

Searches Linking to this Trial