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This study evaluates the clinical and molecular effect of daily exposure to low doses of the fragrance contact allergen oxidized R-limonene. Three groups of participants are included: 1) Patients with a previous positive patch test to oxidized R-Limonene, 2) patients with a previous doubtful patch test to oxidized R-limonene and 3) healthy controls with no contact allergy to oxidized R-limonene
Allergic Contact Dermatitis Due to Cosmetics
ROAT with oxidized R-limonene at 1%, 0.3% and 0.1%, ROAT with oxidized R-limonene at 1%
Department of Dermatology and Allergy, Gentofte University Hospital
Enrolling by invitation
Herlev and Gentofte Hospital
Published on BioPortfolio: 2017-10-23T20:44:13-0400
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Members of the P-450 enzyme family that take part in the hydroxylation of limonene.
A group of cell-surface receptors for oxidatively modified LOW-DENSITY LIPOPROTEINS. The group includes certain SCAVENGER RECEPTORS that contribute to the pathogenesis of ATHEROSCLEROSIS by uptake of oxidized LDL.
A colorless compound formed in the intestines by the reduction of bilirubin. Some is excreted in the feces where it is oxidized to urobilin. Some is reabsorbed and re-excreted in the bile as bilirubin. At times, it is re-excreted in the urine, where it may be later oxidized to urobilin.
A family of thioltransferases that contain two active site CYSTEINE residues, which either form a disulfide (oxidized form) or a dithiol (reduced form). They function as an electron carrier in the GLUTHIONE-dependent synthesis of deoxyribonucleotides by RIBONUCLEOTIDE REDUCTASES and may play a role in the deglutathionylation of protein thiols. The oxidized forms of glutaredoxins are directly reduced by the GLUTATHIONE.
Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.