RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia

2017-11-05 23:53:11 | BioPortfolio


Men with infertility and normal hormone levels have few options for fertility treatment. Previous research suggests that men with infertility may have low levels of the active form of Vitamin A, called retinoic acid, in their testes. In a pilot study of 20 men with low numbers of sperm (<10 million motile sperm), roughly half the men showed improvement in sperm production. Thus, we want to see if retinoic acid administration to men with azoospermia (no sperm present) can initiate sperm production.


Twenty men with infertility, aged 21 - 60, due to azoospermia (no apparent sperm in the ejaculate on two separate occasions) will be enrolled in a single-arm pilot trial of daily oral therapy of 20 mg twice daily of 13-cis retinoic acid for 32 weeks. The impact of treatment on the appearance of sperm in the ejaculate will be determined by monthly semen analyses.

Study Design


Male Infertility, Azoospermia


13-cis retinoic acid


University of Washington Medical Center
United States




University of Washington

Results (where available)

View Results


Published on BioPortfolio: 2017-11-05T23:53:11-0500

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Medical and Biotech [MESH] Definitions

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