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Phase I EGFR BATs in Newly Diagnosed Glioblastoma

2017-11-22 05:06:13 | BioPortfolio

Published on BioPortfolio: 2017-11-22T05:06:13-0500

Clinical Trials [845 Associated Clinical Trials listed on BioPortfolio]

BATs Treatment for Pancreatic Cancer, Phase Ib/II

This protocol will confirm toxicities and estimate the clinical efficacy of combining anti-CD3 x anti-EGFR bispecific antibody (EGFRBi) armed activated T cells (EGFR BATs) given to patient...

Her2-BATS and Pembrolizumab in Metastatic Breast Cancer

This proposal uses HER2Bi armed activated T-cells (HER2 BATs) to target breast cancer in combination with pembrolizumab (PBZ) in women with metastatic breast cancer (MBC). Phase I will det...

HMPL-813 in Treating Patients With Glioblastoma

This is an open-label study, to evaluated epitinib, which is a selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI), to treat glioblastoma patients with EGFR gen...

A Study to Evaluate the Safety, Tolerability and Immunogenicity of EGFR(V)-EDV-Dox in Subjects With Recurrent Glioblastoma Multiforme (GBM)

The purpose of the Cerebral EDV study is to determine the safety and tolerability of EGFR(V)-EDV-Dox in order to establish the best dose level to be used in future studies. The study will ...

GC1118 in Recurrent Glioblastoma Patients With High EGFR Amplification

This study is a phase 2 trial of GC1118, an EGFR monoclonal antibody, for recurrent glioblastoma patients who were treated with standard concurrent chemoradiation.

PubMed Articles [1054 Associated PubMed Articles listed on BioPortfolio]

A Non-Hierarchical Organisation of Tumorigenic NG2 Cells in Glioblastoma promoted by EGFR.

Expression of NG2 identifies an aggressive malignant phenotype in glioblastoma (GBM). Mouse models have implicated NG2 in the genesis, evolution and maintenance of glial cancers, and have highlighted ...

Prognostic implication of alterations in epidermal growth factor receptor and MGMT in glioblastoma.

To investigate the prognostic impact of alterations of epidermal growth factor receptor(EGFR) and MGMT in glioblastoma. The retrospective study included 161 supratentorial glioblastomas diagnosed in ...

Dacomitinib: an investigational drug for the treatment of glioblastoma.

Standard treatment of newly diagnosed glioblastoma (GB) is surgery with radiotherapy and temozolomide, but tumors will recur with a median overall survival of only 15 months. It seems imperative to ex...

Detection of Pseudogymnoascus destructans during Summer on Wisconsin Bats.

White-nose syndrome (WNS) affects bats primarily in winter, with Pseudogymnoascus destructans, the fungus that causes WNS, growing on bats in colder climates as they are hibernating. As a result, near...

Anti-EGFR Resistant Clones Decay Exponentially After Progression: Implications for Anti-EGFR Re-challenge.

Colorectal cancer (CRC) has been shown to acquire RAS and EGFR ectodomain mutations as mechanisms of resistance to EGFR inhibition (anti-EGFR). After anti-EGFR withdrawal, RAS and EGFR mutant clones l...

Medical and Biotech [MESH] Definitions

Order of mammals whose members are adapted for flight. It includes bats, flying foxes, and fruit bats.

Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

A quinazoline derivative and ANTINEOPLASTIC AGENT that functions as a PROTEIN KINASE INHIBITOR for EGFR associated tyrosine kinase. It is used in the treatment of NON-SMALL CELL LUNG CANCER.

Movable feathered or membranous paired appendages by means of which certain animals such as birds, bats, or insects are able to fly.

A genus of softbacked TICKS in the family ARGASIDAE. Most infect birds or bats but a few parasitize terrestrial mammals.

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