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Pilot Study Evaluating Somatostatin Receptor's PET Imaging to Detect Inflammatory Phases of Myocarditis

2017-11-27 05:47:06 | BioPortfolio

Summary

Infectious myocardities are frequent, most of the time viral and can evolve to cardiac insufficiency. The diagnostic is difficult The diagnostic is difficult because they can mimic a myocardial infarct. Approximately 10 % of patients with acute infarction suspected, have a normal angiography, and half of them has in fact a myocarditis, as showed studies of cardiac MRI among which some realized in our department . However, anomalies observed in MRI are not specific and it is necessary to use multiples criterias. A new radiopharmaceutical, the 68Ga-DOTATOC, specific of somatostatine's receptors which are over expressed by the inflammatory cells, has recently showed the capacity to identify myocardities, but only in a small group of 6 patients (Int J Cardiol.2015 ; 194 :44-9.).

We formulate hypotheses:

1. this radiopharmaceutical is enough sensitive to detect most of the acute inflammatory myocardities which are identified by the MRI and

2. , it could maybe allow to identify myocardities with a persistent subacute or chronic inflammation, which are difficult to identify with cardiac MRI, and it would be an new information able to guide the medical decision.

Primary objectif: to determine if PET with 68Ga-DOTATOC is enough sensitive to identify myocardities in acute inflammatory phase by hospitalized patients with suspected acute infaction and with normal angiography and who have a high probability of myocarditie identified by MRI. Disease prevalence will be close to 100 % at baseline Secondary objectives: 1. Estimate the frequency of inflammatory forms (subacute or chronicle), with a 68Ga-DOTATOC PET at 3 to 5 months from baseline, when classic signs of acute inflammatory generally disappeared (CRP, Troponine-I, myocardial oedema in MRI).

2. Analyze the concordance of the results of 68Ga-DOTATOC TEP by two readers

Study Design

Conditions

Myocarditis

Intervention

DOTATOC-68Ga PET initial, DOTATOC-68Ga PET at 6 months, blood sample

Status

Not yet recruiting

Source

Central Hospital, Nancy, France

Results (where available)

View Results

Links

Published on BioPortfolio: 2017-11-27T05:47:06-0500

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Medical and Biotech [MESH] Definitions

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