Track topics on Twitter Track topics that are important to you
Infectious myocardities are frequent, most of the time viral and can evolve to cardiac insufficiency. The diagnostic is difficult The diagnostic is difficult because they can mimic a myocardial infarct. Approximately 10 % of patients with acute infarction suspected, have a normal angiography, and half of them has in fact a myocarditis, as showed studies of cardiac MRI among which some realized in our department . However, anomalies observed in MRI are not specific and it is necessary to use multiples criterias. A new radiopharmaceutical, the 68Ga-DOTATOC, specific of somatostatine's receptors which are over expressed by the inflammatory cells, has recently showed the capacity to identify myocardities, but only in a small group of 6 patients (Int J Cardiol.2015 ; 194 :44-9.).
We formulate hypotheses:
1. this radiopharmaceutical is enough sensitive to detect most of the acute inflammatory myocardities which are identified by the MRI and
2. , it could maybe allow to identify myocardities with a persistent subacute or chronic inflammation, which are difficult to identify with cardiac MRI, and it would be an new information able to guide the medical decision.
Primary objectif: to determine if PET with 68Ga-DOTATOC is enough sensitive to identify myocardities in acute inflammatory phase by hospitalized patients with suspected acute infaction and with normal angiography and who have a high probability of myocarditie identified by MRI. Disease prevalence will be close to 100 % at baseline Secondary objectives: 1. Estimate the frequency of inflammatory forms (subacute or chronicle), with a 68Ga-DOTATOC PET at 3 to 5 months from baseline, when classic signs of acute inflammatory generally disappeared (CRP, Troponine-I, myocardial oedema in MRI).
2. Analyze the concordance of the results of 68Ga-DOTATOC TEP by two readers
DOTATOC-68Ga PET initial, DOTATOC-68Ga PET at 6 months, blood sample
Not yet recruiting
Central Hospital, Nancy, France
Published on BioPortfolio: 2017-11-27T05:47:06-0500
About 40 patients with histologically and/or clinically confirmed and/or suspected NET are anticipated to be enrolled during 3 years from initiating the study. Patients will be recruited ...
The goal of this clinical research study is to use 68GA-DOTATOC instead of the standard-of-care 111-In-pentetreotide as a tracer chemical during PET/CT scans for diagnosing neuroendocrine ...
This is a Phase 2 peptide receptor radionuclide therapy trial of 90Y-DOTATOC in patients with somatostatin receptor positive tumors.
This pilot clinical trial studies gallium Ga 68-edotreotide (68Ga-DOTATOC) positron emission tomography (PET)/computed tomography (CT) in finding brain tumors in younger patients. Diagnost...
This is a prospective, single arm,single centre open-label, phase II study in relapsed or refractory DLBCL and MCL non-Hodgkin's lymphoma (NHL), not suitable to other therapies, included H...
(44)Sc is a promising positron emission tomography (PET) radionuclide (T1/2 = 4.04 hours, Eβ+average = 632 keV) and can be made available, using a cyclotron production route, in substantial...
Combined positron emission tomography (PET) and magnetic resonance imaging (MRI) targeting the prostate-specific membrane antigen (PSMA) with a 68Ga-labelled PSMA-analog (68Ga-PSMA-11) is discussed as...
The aim of this study was to assess the diagnostic performance of simultaneous whole-body Ga-DOTANOC PET/MRI compared with Ga-DOTANOC PET/CT for detection of distant metastatic disease in patients wit...
The development of 68Ge/68Ga generators has made the positron emitting 68Ga isotope widely accessible, raising interest in new chelate complexes of Ga3+. The hexadentate DATAm ligand and its bifunctio...
The existence of theragnostic pairs of radionuclides allows the preparation of radiopharmaceuticals for diagnostic and therapeutic purposes. Radiolanthanides, such as (177)Lu, are successfully used fo...
The fraction of a blood sample, following CENTRIFUGATION, that is distinguished as a thin light-colored layer between the RED BLOOD CELLS, underneath it, and the PLASMA, above it. It is composed mostly of WHITE BLOOD CELLS and PLATELETS.
The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.
The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.
Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.