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Hypermetabolism in ALS Using Six REE Formulas

2018-01-03 13:38:10 | BioPortfolio

Summary

Introduction: About 50-60% of Amyotrophic Lateral Sclerosis (ALS) is characterized by hypermetabolism, defined as 10% or more excess resting energy expenditure (REE) compared to theoretical values. Harris and Benedict's (HB) formula is the equation mainly used to predict REE, but others are also applied in current practice. The present study aimed to assess REE in ALS patients compared to control populations and to compare six formulas commonly used to predict REE.

Nutritional assessments were performed in ALS patients and in two control populations without hypermetabolism: healthy elderly people (control 1) and patients with non-restrictive-eating disorders (control 2). Weight, height and body composition (by bioimpedance analysis) were assessed.

EE was measured (mREE) by indirect calorimetry and calculated (cREE) using HB 1919 and 1984, World Schofield, De Lorenzo, Johnstone and Mifflin formulas. Mann-Whitney and Chi2 tests were used to compare the equations.

Study Design

Conditions

Amyotrophic Lateral Sclerosis

Intervention

Assesment of REE in ALS patients compared to control populations and to compare six formulas commonly used to predict REE.

Location

Limoges
France
87 042

Status

Completed

Source

University Hospital, Limoges

Results (where available)

View Results

Links

Published on BioPortfolio: 2018-01-03T13:38:10-0500

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