Effects of Different Stimuli in Patients With Disorders of Consciousness

2018-01-05 13:47:10 | BioPortfolio


In recent years, promoting wakening attempts in patients with disorders of consciousness are increasing, but there are a lack of objective indicators to evaluate the efficacy and further researches on the brain mechanism during the wakening processing. So, our study first assessed the cerebral response during acoustic stimuli with quantitative EEG, and next, we explored the relationship between brain activation and patients' recovery.


Auditory stimuli have potential beneficial effects on cognitive functions and consciousness in patients with disorders of consciousness (DOC); however, precise and accurate quantitative indices to estimate cerebral activation to different auditory stimuli remain scarce. In this study, we assessed the response of different brain regions to three acoustic stimuli using quantitative electroencephalography (QEEG) and further investigated the predictive value of QEEG in the prognosis of DOC. We enrolled 14 healthy controls (HC) and 14 in-patients with DOC, and monitored each of their brain responses to the three acoustic stimuli. Furthermore, we determined 1-year outcomes of patients using the Glasgow Outcome Scale.

Study Design


Disorder of Consciousness


music,name,and noise sound




First Affiliated Hospital of Zhejiang University

Results (where available)

View Results


Published on BioPortfolio: 2018-01-05T13:47:10-0500

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