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Safety and Efficacy of ADS-5102 in Multiple Sclerosis Patients With Walking Impairment

2018-02-21 19:15:12 | BioPortfolio

Published on BioPortfolio: 2018-02-21T19:15:12-0500

Clinical Trials [1007 Associated Clinical Trials listed on BioPortfolio]

Safety and Efficacy of ADS-5102 in Patients With Multiple Sclerosis and Walking Impairment

This is a multi-center, randomized, double-blind, placebo-controlled, 2-arm, parallel group study of ADS-5102 extended release (ER) capsules, an investigational formulation of amantadine, ...

A Safety and Efficacy Study of ADS-5102 in Patients With Multiple Sclerosis and Walking Impairment

This is a multicenter, open-label extension (OLE) study of ADS-5102 (amantadine extended release [ER] capsules) in subjects with MS and walking impairment who completed a prior study of AD...

Open-Label Safety Study of ADS-5102 in PD Patients With LID

This is a 52-week open-label study to evaluate the safety and tolerability of ADS-5102 oral capsules, an extended release formulation of amantadine, in Parkinson's Disease (PD) patients wi...

Efficacy and Safety Study of ADS-5102 in PD Patients With Levodopa-Induced Dyskinesia

This is a multi-center, randomized, double-blind, placebo-controlled, 2-arm, parallel group study to evaluate the efficacy and safety of ADS-5102 extended release (ER) capsules, an investi...

Evaluation of Self-reported Walking Impairment in Predominantly Illiterate Patients

The purpose of this study is to test the routine feasibility of an image tool adapted from the WELCH questionnaire ( Walking estimated limitation calculated by history) to estimate walking...

PubMed Articles [3569 Associated PubMed Articles listed on BioPortfolio]

Impact of dyskinesia on activities of daily living in Parkinson's disease: Results from pooled phase 3 ADS-5102 clinical trials.

In Parkinson's disease, dyskinesias result from disease progression and chronic levodopa therapy. Using Unified Dyskinesia Rating Scale (UDysRS) data pooled from two pivotal trials of ADS-5102 (amanta...

Neither total muscle activation nor co-activation explains the youthful walking economy of older runners.

Older adults (≥65 years) exhibit greater metabolic rates during walking (worse walking economy) compared to young adults. Yet, previous research suggests that habitual running, but not habitual walk...

Moderate Renal Impairment Does Not Impact the Ability of CSL112 (Apolipoprotein A-I Human) to Enhance Cholesterol Efflux Capacity.

CSL112 (apolipoprotein A-I [human]) is a novel intravenous formulation of plasma-derived apolipoprotein A-I (apoA-I) that enhances cholesterol efflux capacity. Renal impairment is a common comorbidity...

Visual scanning behavior during distracted walking in healthy young adults.

An epidemic of pedestrian accidents when walking while texting suggests that people are less aware of their surroundings during distracted walking, and highlights the importance of visual scanning for...

The effect of walking path configuration on gait in adults with Alzheimer's dementia.

Walking is a cognition intensive activity and impaired walking is associated with an increased fall risk in people with Alzheimer's dementia (AD). Walking in a curved path configuration increases comp...

Medical and Biotech [MESH] Definitions

An activity in which the body advances at a slow to moderate pace by moving the feet in a coordinated fashion. This includes recreational walking, walking for fitness, and competitive race-walking.

The rate at which steps are made while walking.

Impairment of the ability to coordinate the movements required for normal ambulation (WALKING) which may result from impairments of motor function or sensory feedback. This condition may be associated with BRAIN DISEASES (including CEREBELLAR DISEASES and BASAL GANGLIA DISEASES); SPINAL CORD DISEASES; or PERIPHERAL NERVOUS SYSTEM DISEASES.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

Professionals skilled at diagnostic testing of hearing, HEARING IMPAIRMENT, and CORRECTION OF HEARING IMPAIRMENT by non-medical or non-surgical means.

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