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Optimizing PrEP Adherence for Young Men Who Have Sex With Men

2018-04-17 08:47:09 | BioPortfolio

Summary

The specific aims of this study are:

1. To explore perceived facilitators and barriers to initiating and adhering to HIV PRE-EXPOSURE PROPHYLAXIS (PrEP) among at-risk YOUNG MEN WHO HAVE SEX WITH MEN (YMSM).

2. To assess the acceptability and feasibility of a culturally-tailored peer navigator program to optimize adherence to PrEP among YMSM.

Description

New HIV infections occur at a disproportionately high rate among young men who have sex with men (YMSM).Oral pre-exposure prophylaxis (PrEP) can reduce HIV acquisition among MSM over 90% when adherence levels are high, and increasing the effective use of PrEP among YMSM is one of the highest priorities in HIV prevention. However, YMSM face multiple barriers to initiating and adhering to PrEP, including structural barriers (e.g. housing insecurity), psychosocial factors (e.g. substance use, depression), underestimation of their risk for acquiring HIV, and ambivalence about using PrEP due to medical mistrust. In an open-label study of PrEP use by 200 YMSM, only one-third of participants had protective levels of drug in their blood at 1 year despite intensive adherence counseling, and HIV incidence was high at 3% per year. When PrEP is prescribed to YMSM in care settings, where adherence support is less intensive than in clinical studies, adherence levels, and thus effectiveness, are likely to be even lower. Without strategies to optimize adherence to PrEP for these youth, PrEP is unlikely to have a major impact on HIV incidence for YMSM.

One approach to overcoming the multi-factorial barriers that prevent YMSM from adhering to PrEP is the use of peer health system navigators. Navigators are healthcare workers who are trained to support adherence and retention in care for individuals who are at risk for suboptimal adherence. For YMSM who use PrEP, peer navigators could support adherence by connecting youth with resources to address their unmet structural and psychosocial needs and by helping them to negotiate the complexities of healthcare systems. An NICHD-funded study conducted in Boston (SMILE: Strategic Multisite Initiative for the Identification, Linkage and Engagement in Care of Youth with Undiagnosed HIV) found that peer navigation was highly acceptable for newly diagnosed HIV-infected youth, so it is likely that YMSM will find peer navigation to be acceptable for PrEP. As navigators have been used for over a decade to improve adherence in HIV-infected persons, and an evaluation showed that HIV-infected persons who used navigators had higher rates of virologic suppression, it is important to test whether peer navigation can optimize adherence to PrEP for YMSM.

Our long-term goal is to optimize adherence to PrEP for YMSM and thus decrease HIV incidence. The objective of this study, the first step towards our goal, is to develop and pilot test a peer navigator program to optimize adherence to PrEP for YMSM. We will recruit at-risk YMSM from an LGBTQ Youth-focused community health center with PrEP expertise, the Sidney Borum Jr. Health Center. The Borum Center provides care to 1200 YMSM aged 12-29 annually, half of whom are Black or Latino and 20% of whom are homeless. As incidence rates for HIV (2%) and syphilis (9%) in 2015 were over 20 and 100-fold higher at this center than in the general Boston population, and its clinicians initiate PrEP for 3-4 YMSM monthly, the Borum Center is an ideal setting to explore adherence to PrEP among the highest risk YMSM. Our specific aims are:

Aim 1. To explore perceived facilitators and barriers to initiating and adhering to PrEP among at-risk YMSM. We will conduct in-depth qualitative interviews with 32 YMSM at the Borum Center, including 8 youth who have not yet discussed PrEP with clinicians, 8 who have declined PrEP when offered by clinicians, 8 who have been adherent to PrEP, and 8 with suboptimal adherence. Discussions will include in-depth exploration of YMSM attitudes and intentions regarding PrEP and PrEP peer navigators. We will use purposive sampling to recruit a diverse sample with respect to race, ethnicity, and age, including youth who are minors.

Aim 2. To assess the acceptability and feasibility of a culturally-tailored peer navigator program to optimize adherence to PrEP among YMSM. A PrEP peer navigator program will be adapted from the SMILE study and will be informed by our findings from Aim 1. We will pilot test the program for acceptability and feasibility with 15 YMSM who are newly initiating PrEP at the Borum Center. Secondary outcomes include retention in PrEP care and adherence to PrEP, as measured by dried blood spot testing, at 3 and 6 months.

Study Design

Conditions

Pre-Exposure Prophylaxis

Intervention

Peer Health Navigator for PrEP

Location

The Fenway Institute
Boston
Massachusetts
United States
02215

Status

Recruiting

Source

Fenway Community Health

Results (where available)

View Results

Links

Published on BioPortfolio: 2018-04-17T08:47:09-0400

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Medical and Biotech [MESH] Definitions

A method of disease prevention (abbreviated PrEP) which involves the administration of drugs to at-risk persons who have not been exposed to the disease-causing agent.

The prevention of infection or disease following exposure to a pathogen. This is most frequently addressed by administering a vaccine or anti-viral medication following exposure to a virus.

The effect or sway that a PEER GROUP exerts on the beliefs, value systems and behavior of each member of a group. The social expectations for individuals to conform to peer group influence is known as peer pressure.

An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.

The concurrent or retrospective review by practicing physicians or other health professionals of the quality and efficiency of patient care practices or services ordered or performed by other physicians or other health professionals (From The Facts On File Dictionary of Health Care Management, 1988).

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