Antiretroviral Treatment Guided by Proviral Genotype: Pilot Trial of Proof of Concept.

2018-06-03 22:30:14 | BioPortfolio


Phase IIa, open clinical trial, pilot, single arm and proof of concept.


Proof of concept trial evaluating safety and efficacy of treatment with Dolutegravir (DTG) + lamivudine (3TC) once daily in suppressed participants with history of previous treatment with 3TC or emtricitabine (FTC). Half of the participants will have history of failure with 3TC or FTC and M184V/I or K65R/E/N mutations in previous plasma genotypes, although to be eligible these mutations cannot be detectable at study entry in proviral DNA.

Study Design




Dolutegravir (DTG)


Hospital 12 de Octubre




Instituto de Investigación Hospital Universitario La Paz

Results (where available)

View Results


Published on BioPortfolio: 2018-06-03T22:30:14-0400

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Medical and Biotech [MESH] Definitions

Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.

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An infection at a specific location that may spread to another region of the body.

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