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Antiretroviral Treatment Guided by Proviral Genotype: Pilot Trial of Proof of Concept.

2018-06-03 22:30:14 | BioPortfolio

Summary

Phase IIa, open clinical trial, pilot, single arm and proof of concept.

Description

Proof of concept trial evaluating safety and efficacy of treatment with Dolutegravir (DTG) + lamivudine (3TC) once daily in suppressed participants with history of previous treatment with 3TC or emtricitabine (FTC). Half of the participants will have history of failure with 3TC or FTC and M184V/I or K65R/E/N mutations in previous plasma genotypes, although to be eligible these mutations cannot be detectable at study entry in proviral DNA.

Study Design

Conditions

HIV-1-infection

Intervention

Dolutegravir (DTG)

Location

Hospital 12 de Octubre
Madrid
Spain
28041

Status

Recruiting

Source

Instituto de Investigación Hospital Universitario La Paz

Results (where available)

View Results

Links

Published on BioPortfolio: 2018-06-03T22:30:14-0400

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Switch to dolutegravir is well tolerated in Thais with HIV infection.

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Medical and Biotech [MESH] Definitions

Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.

A nontuberculous infection when occurring in humans. It is characterized by pulmonary disease, lymphadenitis in children, and systemic disease in AIDS patients. Mycobacterium avium-intracellulare infection of birds and swine results in tuberculosis.

Infection involving the tissues or organs in the PELVIS.

Infection in humans and animals caused by fungi in the class Zygomycetes. It includes MUCORMYCOSIS and entomophthoramycosis. The latter is a tropical infection of subcutaneous tissue or paranasal sinuses caused by fungi in the order Entomophthorales. Phycomycosis, closely related to zygomycosis, describes infection with members of Phycomycetes, an obsolete classification.

An infection at a specific location that may spread to another region of the body.

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