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Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients

2018-06-25 04:40:12 | BioPortfolio

Summary

Poor ovarian response population of ART are considered the biggest challenge for providers. Hitherto, no one protocol has been proven to be effect in this subgroup of IVF patients.

Metoclopramide belongs to the antiemetic group, used for motion sickness and during early gestation for hyperemesis gravidarum.

The mechanism of action is antagonisim to dopamine receptors. We hypothesize than by blocking dopamine receptors and decreasing the dopaminergic tone there is a possibility to increase the sensitivity of ovarian response to gonadotropins during controlled ovarian stimulation and result in increased oocyte retrival.

Study Design

Conditions

Poor Responders in IVF

Intervention

Metoclopramide, Placebo Oral Tablet

Status

Not yet recruiting

Source

Barzilai Medical Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2018-06-25T04:40:12-0400

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