Investigation of the Heart and the Clinical Course of Acute Coronary Syndrome in Patients With Non-obstructive Lesion of the Coronary Arteries

2018-07-06 08:02:13 | BioPortfolio


The purpose of this study is to improve the differential diagnosis and clinical outcomes of acute coronary syndrome with non-obstructive coronary arteries, to investigate the relationship between the structural and functional state of the heart and the clinical course of the disease.


The study non randomized, opened, controlled. Approximately in 1 to 14% of cases,among patients with acute myocardial infarction, there are no obstructive changes in the coronary arteries according to invasive coronary angiography (defined as stenosis of >50%, ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation, 2017). Highly sensitive Troponin I is a marker of damage to cardiomyocytes, but it is not underlying mechanism of myocardial damage.

It is planned to study 40 patients with acute coronary syndrome. On admission, they will receive the standard treatment of ACS with and without ST elevation. Within 24 hours they will be performed diagnostic coronary angiography. In case of non stenotic atherosclerosis of coronary artery (normal / stenosis < 50%)the patients are planned for cardiac contrast MRI, which will identify both ischemic and non-ischemic causes of acute coronary syndrome; MSCT with the purpose for assessing the coronary arteries, the structure of the atherosclerotic plaque; scintigraphy of the myocardium to reveal a perfusion defect.

The frequency of carriers of unfavorable factors of hemostasis system and folate-cycle enzymes in relation to the risk of thrombophilia of allelic variants of genes will be studied, their significance in the development of thrombosis in acute myocardial infarction will be assessed, as well as the profile of markers of proinflammatory and anti-inflammatory response, their significance in the development of acute myocardial infarction in patients with non-obstructive coronary atherosclerosis in comparison with the control group. In a 1 year, repeated studies will be conducted to dynamically assess the structural and functional state of the heart.

Study Design


Acute Coronary Syndrome


MSCT , CMR imaging.


Vyacheslav Ryabov
Tomsk, Tomskii Region
Russian Federation




Tomsk National Research Medical Center of the Russian Academy of Sciences

Results (where available)

View Results


Published on BioPortfolio: 2018-07-06T08:02:13-0400

Clinical Trials [4382 Associated Clinical Trials listed on BioPortfolio]

Coronary Computed Tomography for Systematic Triage of Acute Chest Pain Patients to Treatment (CT-STAT)

This is a prospective, randomized multicenter trial comparing MSCT to standard of care (SOC) diagnostic treatment in the triage of Emergency Department (ED) low to intermediate risk chest ...

Optical Coherence Tomography in Acute Coronary Syndrome

The OPTICO-ACS- study program - combining for the first time in vivo characterization of the ACS-causing "culprit lesion" by intracoronary imaging technique with optical coherence tomograp...

A Multicentre, Pilot Study to Evaluate the Safety and the Feasibility of Planning and Execution of Surgical Revascularization in Patients With Complex Coronary Artery Disease, Based Solely on MSCT Imaging Utilizing GE Healthcare Revolution CT and HeartFlo

The CABG-REVOLUTION study is an investigator-initiated single-arm, multicentre, prospective study for patients with 3-vessel disease (with or without left-main involvement) referred to CAB...

Myeloperoxidase and Multi-Markers In the Diagnosis of Diagnoses of Acute Coronary Syndrome (MIDAS) - Sample Procurement

The purpose of the study is to procure blood samples from patients who present to the Emergency Department with suspected ACS (Acute Coronary Syndrome).

Jakarta Acute Coronary Syndrome Registry

Jakarta acute coronary syndrome enrolled patients with acute coronary syndrome admitted to the emergency department of a national cardiac referral hospital.

PubMed Articles [17332 Associated PubMed Articles listed on BioPortfolio]

Association of High-Density Calcified 1K Plaque With Risk of Acute Coronary Syndrome.

Plaque morphologic measures on coronary computed tomography angiography (CCTA) have been associated with future acute coronary syndrome (ACS). However, the evolution of calcified coronary plaques by n...

Coexistence of acute takotsubo syndrome and acute coronary syndrome.

Takotsubo syndrome (TS) is an acute cardiac condition with presentation indistinguishable from acute coronary syndrome (ACS), and mechanism independent of epicardial coronary obstruction. Acute corona...

Low-risk Non-ST-Elevation Acute Coronary Syndrome and Normal Troponin: Do We Need Further Evaluation?

With the recent introduction of high-sensitivity troponin (hsTn), the incremental benefit of stress myocardial perfusion imaging (MPI) in the evaluation of patients who present to the emergency depart...

Reduced regional strain rate is the most accurate dysfunction in predicting culprit lesions in patients with acute coronary syndrome.

Predicting culprit lesions in acute coronary syndrome (ACS) could be a challenge. The aim of this study was to assess the accuracy of regional wall motion abnormalities (RWMA) using various echocardio...

Resource Utilization and Costs Associated With Percutaneous Coronary Intervention When Treating Patients With Acute Coronary Syndrome in the Mexican National Institute of Cardiology "Ignacio Chávez".

The treatment of acute coronary syndrome (ACS) using percutaneous coronary intervention (PCI) is a frequent intervention with a high economic impact.

Medical and Biotech [MESH] Definitions


The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.

Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.

An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode but that does not usually result in MYOCARDIAL INFARCTION.

A congenital coronary vessel anomaly in which the left main CORONARY ARTERY originates from the PULMONARY ARTERY instead of from AORTA. The congenital heart defect typically results in coronary artery FISTULA; LEFT-SIDED HEART FAILURE and MITRAL VALVE INSUFFICIENCY during the first months of life.

More From BioPortfolio on "Investigation of the Heart and the Clinical Course of Acute Coronary Syndrome in Patients With Non-obstructive Lesion of the Coronary Arteries"

Quick Search

Relevant Topics

Cardiology is a specialty of internal medicine.  Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...

Cardiovascular disease (CVD)
Acute Coronary Syndromes (ACS) Blood Cardiovascular Dialysis Hypertension Stent Stroke Vascular Cardiovascular disease (CVD) includes all the diseases of the heart and circulation including coronary heart disease (angina...

Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...

Searches Linking to this Trial