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Real-world Daptomycin Use in Chinese ICUs

2018-07-23 12:33:12 | BioPortfolio

Published on BioPortfolio: 2018-07-23T12:33:12-0400

Clinical Trials [47 Associated Clinical Trials listed on BioPortfolio]

A Study to Evaluate Daptomycin Given During Dialysis and After Dialysis

The purpose of this study is to determine whether daptomycin at a higher dose given during the last 30 minutes of a dialysis session is equal to a lower dose of daptomycin given after a di...

Pharmacokinetic Study of Daptomycin in Healthy Chinese Subjects Living in China

The primary objective of this study is to characterise the pharmacokinetics and dose proportionality of daptomycin after single and multiple (once daily) 4mg/kg and 6 mg/kg doses of daptom...

An Open Label Study to Describe the Pharmacokinetics of Daptomycin in Infants

This is a safety and pharmacokinetic study of single-dose daptomycin in infants > 48 hours and < 120 days of age with suspected systemic infections. The investigators will enroll a total ...

Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis

multicenter, randomized, double blind study to describe the safety and efficacy of daptomycin (6 mg/kg q24h) with and without concomitant initial gentamicin combination therapy in the trea...

Daptomycin in the Treatment of Patients With Renal Insufficiency and Complicated Skin and Skin Structure Infections

This is a Phase 4, randomized, open-label, multicenter, comparative study designed to further evaluate the pharmacokinetics of intravenous (i.v.) daptomycin and the safety and efficacy of ...

PubMed Articles [3678 Associated PubMed Articles listed on BioPortfolio]

Comparison of the Effects of Daptomycin on Bacterial and Model Membranes.

Daptomycin is a phosphatidylglycerol specific, calcium dependent membrane-active antibiotic that has been approved for the treatment of Gram-positive infections. A recent Bacillus subtilis study found...

A Fixed versus Weight-Based Dosing Strategy of Daptomycin may Improve Safety in Obese Adults.

To compare daptomycin exposures and predicted safety outcomes with a simulated weight-based and fixed dose in morbidly-obese and non-obese subjects METHODS: We performed a nonparametric population pha...

Simple LC-MS/MS Methods Using Core-Shell ODS Microparticulate for the Quantitation of Total and Free Daptomycin in Human Plasma.

Daptomycin, a cyclic lipopeptide antibiotic, displays high plasma protein binding. This study developed the simple method of liquid chromatographic separation using a core shell ODS microparticulate c...

Comparison of Risk Factors and Outcomes of Daptomycin-Susceptible and -Nonsusceptible Vancomycin-Resistant Enterococcus faecium Infections in Liver Transplant Recipients; A reply to Lewis et al.

Daptomycin resistance is emerging and is associated with liver transplantation (LTX). The outcomes of patients infected with daptomycin-nonsusceptible-enterococci (DNSE) with minimum-inhibitory-concen...

Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature.

Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often ...

Medical and Biotech [MESH] Definitions

A cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.

A study in which observations are made before and after an intervention, both in a group that receives the intervention and in a control group that does not.

A study that uses observations at multiple time points before and after an intervention (the "interruption"), in an attempt to detect whether the intervention has had an effect significantly greater than any underlying trend over time.

Procedures and programs that facilitate the development or skill acquisition in infants and young children who have disabilities, who are at risk for developing disabilities, or who are gifted. It includes programs that are designed to prevent handicapping conditions in infants and young children and family-centered programs designed to affect the functioning of infants and children with special needs. (From Journal of Early Intervention, Editorial, 1989, vol. 13, no. 1, p. 3; A Discursive Dictionary of Health Care, prepared for the U.S. House of Representatives Committee on Interstate and Foreign Commerce, 1976)

Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.

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