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Short vs. Long Antibiotic Treatment of Implant-free Osteoarticular Infections

2018-08-01 14:26:14 | BioPortfolio

Summary

We test the working hypothesis if 4 weeks of systemic antibiotic treatment in implant-related orthopaedic infections is non-inferior to 6 weeks after complete removal of the infected implant. Randomization 1:1.

Description

Osteoarticular infections related to orthopaedic implants are associated with substantial morbidity, prolongation of hospital stay, and additional costs. Due to the increasing number of patients with orthopaedic implants in Switzerland, similar to the rest of Europe and elsewhere, the number of infections is expected to increase. While the surgical treatment of these infections has been well studied, the ideal duration of antibiotic therapy after removal (explantation) of the infected implant remains unknown. For almost 40 years, the recommended total duration of post-explantational antibiotic therapy has been 6 weeks. This recommendation is based on expert's personal experience rather than on prospective randomized studies. Shorter treatment would decrease antibiotic-related adverse events and costs hospital stay for patients awaiting an eventual reinsertion of a new implant. If physicians and surgeon prescribe antibiotics for 6 weeks, this duration should be at least supported by evidence.

Study Design

Conditions

Implant Infection

Intervention

Removal of infected implant, Antibiotic durations

Location

Geneva University Hospitals
Geneva
Switzerland
1211

Status

Terminated

Source

University Hospital, Geneva

Results (where available)

View Results

Links

Published on BioPortfolio: 2018-08-01T14:26:14-0400

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