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Treatment of Wounds Using Oasis® ECM

2018-08-19 20:17:13 | BioPortfolio

Summary

The purpose of this study is to demonstrate the clinical performance, safety, and cost-effectiveness of Oasis ECM as a treatment for different types of chronic wounds in the community setting in the United Kingdom. The Oasis ECM is commercially available for the treatment of partial and full-thickness skin wounds, including chronic wounds, wounds from trauma, and wounds that occur during surgery. The ability of the Oasis ECM to promote the healing of chronic wounds will be evaluated in this study.

About 40 patients (men or women) over 18 years old will be involved in this study at up to 3 different centres in the United Kingdom.

Study Design

Conditions

Non-healing Wound

Intervention

Oasis extracellular matrix

Status

Not yet recruiting

Source

Cook Biotech Incorporated

Results (where available)

View Results

Links

Published on BioPortfolio: 2018-08-19T20:17:13-0400

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Medical and Biotech [MESH] Definitions

A secreted matrix metalloproteinase that may play a role in matrix degradation during WOUND HEALING. It is expressed at high levels by KERATINOCYTES, suggesting its role in keratinocyte migration.

A secreted matrix metalloproteinase which is highly expressed by MACROPHAGES where it may play a role in INFLAMMATION and WOUND HEALING.

The application of a vacuum across the surface of a wound through a foam dressing cut to fit the wound. This removes wound exudates, reduces build-up of inflammatory mediators, and increases the flow of nutrients to the wound thus promoting healing.

A family of extracellular matrix glycoproteins that is structurally similar to LATENT TGF-BETA BINDING PROTEINS, but contain additional TGF-beta binding domains, in addition to unique domains at their N and C-terminals. Fibrillins assemble into 10-12 nm MICROFIBRILS that function in a variety of cell interactions with the EXTRACELLULAR MATRIX and developmental processes such as ELASTIC TISSUE maintenance and assembly, and the targeting of growth factors to the extracellular matrix.

Dressings comprised of a self-adhesive matrix to which hydrophilic absorbent particles are embedded. The particles consist of CELLULOSE derivatives; calcium ALGINATES; PECTINS; or GELS. The utility is based on providing a moist environment for WOUND HEALING.

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