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Effect of Chemotherapy on PD-L1 in NSCLC

2018-10-17 12:26:20 | BioPortfolio

Summary

PD-L1 is identified as an important biomarkers for predicting PD-1/PD-L1 inhibitors in advanced Non-Small Cell Lung Cancer. Several previous clinical trials have demonstrated that chemotherapy could enhance the efficacy of PD-1/L1 immunotherapy in NSCLC such as Checkmate-227, Impower-150, Keynote-189, etc. Pre-clincial experiment shows that chemotherapy could increase CD8 TIL infiltration in tumor microenvironment, activate T cell immune reaction. However, it remains unclear whether chemotherapy could affect PD-L1 in advanced NSCLC patients. The present study aims to evaluate whether PD-L1 will change after receiving chemotherapy in advanced NSCLC patients.

Study Design

Conditions

Chemotherapy

Intervention

PD-L1 group

Location

Shanghai Changzheng Hospital
Shanghai
Shanghai
China
200003

Status

Recruiting

Source

Shanghai Changzheng Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2018-10-17T12:26:20-0400

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Medical and Biotech [MESH] Definitions

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