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A RETROspective Study of Patients With TK2d

2018-10-16 12:40:22 | BioPortfolio

Published on BioPortfolio: 2018-10-16T12:40:22-0400

Clinical Trials [178 Associated Clinical Trials listed on BioPortfolio]

Evaluation of Thymidine Kinase Activity in the Serum of Patients With Solid Tumors

This study aimed to evaluate serum thymidine kinase 1 (TK1) activity as a marker for solid tumors and more specifically in: preoperative testing for prediction of disease recurrence and su...

TK008: Efficacy Study on the Strategy of Herpes Simplex Virus Thymidine Kinase Donor Lymphocytes to Treat Patients With High Risk Acute Leukemia

The main objective of this randomized trial is to demonstrate the efficacy in reducing Non-Relapse Mortality of Herpes Simplex Virus Thymidine kinase donor lymphocytes add back strategy ve...

Treatment of TK2 Deficiency With Thymidine and Deoxycytidine

Patients with confirmed mitochondrial DNA depletion syndrome 2 (thymidine kinase 2 [TK2] deficiency) have reduced levels of nucleotides (deoxythymidine monophosphate and deoxycytidine mono...

124I-FIAU Imaging in EBV and KSHV Associated Cancers

This research is being done to determine whether viral thymidine kinase (TK) expression in Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV) virus-associated tumors is suff...

Phase II Study of Ribose, Uridine, and Thymidine for a Complex Syndrome Involving Excessive 5'-Nucleotidase Activity

OBJECTIVES: I. Evaluate the efficacy of oral ribose in patients with a complex 5'-nucleotidase syndrome who have not received uridine (UR) and thymidine (TDR). II. Evaluate the efficacy...

PubMed Articles [3070 Associated PubMed Articles listed on BioPortfolio]

Thymidine Kinase PET Reporter Gene Imaging of Cancer Cells In Vivo.

Positron emission tomography (PET) is a three dimensional imaging modality that detects the accumulation of radiolabeled isotopes in vivo. Ectopic expression of a thymidine kinase reporter gene allows...

Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer.

Successful inhibition of thymidylate synthase (TS) by pemetrexed, a TS inhibitor, results in a reproducible transient burst or "flare" in thymidine salvage pathway activity at 2 hrs. of therapy which ...

Relationship Between Thymidine Kinase 1 Expression and Trifluridine/Tipiracil Therapy in Refractory Metastatic Colorectal Cancer: A Pooled Analysis of 2 Randomized Clinical Trials.

High thymidine kinase 1 (TK1) activity increases the incorporation of trifluridine (FTD) into DNA; thus, FTD antitumor activity is likely to increase in patients with high tumoral TK1 activity. To dat...

Luminescent ultralong microfiber prepared via supramolecular self-assembly of lanthanide and thymidine in water.

Luminescent materials are of great potential for many fields such as fluorescent sensing and medical imaging. Herein, the construction of lanthanide based luminescent ultralong microfibers through sup...

Thymidylate kinase is critical for DNA repair via ATM-dependent Tip60 complex formation.

Cellular supply of deoxythymidine triphosphate (dTTP) is crucial for DNA replication and repair. Thymidylate kinase (TMPK) catalyzes the conversion of thymidine monophosphate to thymidine diphosphate,...

Medical and Biotech [MESH] Definitions

An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.

The enzyme catalyzing the transfer of 2-deoxy-D-ribose from thymidine to orthophosphate, thereby liberating thymidine. EC 2.4.2.4.

A 150-kDa MAP kinase kinase kinase that may play a role in the induction of APOPTOSIS. It has specificity for MAP KINASE KINASE 3; MAP KINASE KINASE 4; and MAP KINASE KINASE 6.

A 195-kDa MAP kinase kinase kinase with broad specificity for MAP KINASE KINASES. It is found localized in the CYTOSKELETON and can activate a variety of MAP kinase-dependent pathways.

A 70-kDa MAP kinase kinase kinase with specificity for MAP KINASE KINASE 5. It is activated during the cellular response to GROWTH FACTORS, oxidative stress, and hyperosmotic conditions.

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