Topics

Cryoneurolysis of Arnold's Nerve and Follow-up by Tractography: Feasibility Study

2018-11-14 18:37:14 | BioPortfolio

Summary

According to the World Health Organization (WHO), headaches are one of the most common nervous system disorders. The therapeutic strategy is well established for certain subcategories of headache. On the other hand, when headaches become refractory, some nerves may become the target of targeted therapies. This is the case of the Arnold nerve, also called the great occipital nerve, which is involved in certain pathologies, both physiopathologically and therapeutically. The Arnold nerve infiltration has a relatively short duration of effectiveness (about 1 month on average), some teams have reported the interest of achieving a destruction of the Arnold nerve by radio frequency, with extended durations of efficiencies to several months. The use of cryoneurolysis has been known for a long time and its effectiveness in the management of cranio-facial pain is already reported. It is thus possible to obtain, at the end of the cryoanalgesia needle, very low temperatures around -40 ° C, which leads to the formation of an ice cube and, where appropriate, the freezing of the structures (nerves among others) to the needle contacts. This induces the formation of microcrystals leading to irreversible lesions of vasa-nervorums resulting in an endoneural edema. In the long run, it appears a Wallerian degeneration without destruction of this endoneurum. This is associated with the lack of destruction of the structure of the Schwann cell. Nerve regeneration is possible.

The diffusion MRI study allows tractographic reconstruction of the nerves. This is the only imaging technique that focuses on the fibrillar structure of the nerves, thus enabling the detection of nerves throughout its path. It is a morphological imaging technique nevertheless it also allows a quantitative analysis of the nerve through certain parameters.

The Investigators hypothesize that the cryoneurolysis of the Arnold nerve will result in the disappearance of visualization of the nerve by MRI tractography. The effect of cryoneurolysis on Arnold nerves, as on other peripheral nerves through diffusion MRI has never been described. The follow-up of MRI patients who had undergone cryoneurolysis would make it possible to study the behavior of these nerves after cryoneurolysis, and to correlate the aspect in tractography with the clinical data. Painful recurrence can then be correlated with visualization of the nerves by MRI.

Study Design

Conditions

Neuralgia Arnold

Intervention

MRI

Location

CHU Grenoble-Alpes
Grenoble
France
38043

Status

Not yet recruiting

Source

University Hospital, Grenoble

Results (where available)

View Results

Links

Published on BioPortfolio: 2018-11-14T18:37:14-0500

Clinical Trials [151 Associated Clinical Trials listed on BioPortfolio]

Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia

This research study will look at the safety (e.g., the occurrence of side effects) and efficacy (how well the drug works in reducing trigeminal neuralgia attacks) of a drug called lamotrig...

Safety and Efficacy of Gabapentin in Postherpetic Neuralgia

Gabapentin and pregabalin are treatments for some types of neuropathic pain, including postherpetic neuralgia (PHN). However, these treatments usually need to be taken 3 times a day for ef...

Safety and Efficacy of Gabapentin in Postherpetic Neuralgia

Gabapentin and pregabalin are treatments for some types of neuropathic pain, including postherpetic neuralgia (PHN). However, these treatments usually need to be taken 3 times a day for e...

Classical Trigeminal Neuralgia and Sodium Channel Mutations

The most common cause of trigeminal neuralgia is considered to be a neurovascular contact. However, this etiological factor only seem to be present in half of the patient group. Thus the e...

Safety and Efficacy of AGN201781 in Neuropathic Pain

This study will explore the safety and efficacy of AGN201781 in patients with postherpetic neuralgia or post-traumatic peripheral neuralgia

PubMed Articles [97 Associated PubMed Articles listed on BioPortfolio]

Rare case of concurrent glossopharyngeal and trigeminal neuralgia, in which glossopharyngeal neuralgia was possibly induced by postoperative changes following microvascular decompression for trigeminal neuralgia.

Analysis of the Risk Factors for Postherpetic Neuralgia.

Postherpetic neuralgia is the most common complication of herpes zoster, affecting 30% of patients. It seriously affects the quality of life of patients and the curative effect of treatment is limited...

Arnold J. Levine and my career development.

I have known Arnold J. Levine, whom we fondly call Arnie, for over 22 years. Three important decisions in my career-job offer by Princeton University, the move from Princeton to Tsinghua, and profess...

Atlantoaxial fixation as treatment of trigeminal neuralgia in a patient having basilar invagination.

We report a case of a 36-year-old male patient who presented with primary symptom of trigeminal neuralgia for a period of 2 years. Investigations revealed presence of basilar invagination and an ectat...

Recurrent Trigeminal Neuralgia Caused by a Subsequently Developed Offending Artery within a Short Period: A Case Report.

Recurrent trigeminal neuralgia after successful microvascular decompression is not rare.

Medical and Biotech [MESH] Definitions

Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.

Neuralgic syndromes and other conditions which feature chronic or recurrent FACIAL PAIN as the primary manifestation of disease. Disorders of the trigeminal and facial nerves are frequently associated with these conditions.

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

Pain associated with a damaged PUDENDAL NERVE. Clinical features may include positional pain with sitting in the perineal and genital areas, sexual dysfunction and FECAL INCONTINENCE and URINARY INCONTINENCE.

Congenital, or rarely acquired, herniation of meningeal and spinal cord tissue through a bony defect in the vertebral column. The majority of these defects occur in the lumbosacral region. Clinical features include PARAPLEGIA, loss of sensation in the lower body, and incontinence. This condition may be associated with the ARNOLD-CHIARI MALFORMATION and HYDROCEPHALUS. (From Joynt, Clinical Neurology, 1992, Ch55, pp35-6)

More From BioPortfolio on "Cryoneurolysis of Arnold's Nerve and Follow-up by Tractography: Feasibility Study"

Quick Search

Relevant Topics

Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...

Anesthesiology
An anesthesiologist (US English) or anaesthetist (British English) is a physician trained in anesthesia and perioperative medicine. Anesthesiologists are physicians who provide medical care to patients in a wide variety of (usually acute) situations. ...


Searches Linking to this Trial