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Transcranial Magnetic Stimulation for Treatment of Methamphetamine Use Disorder

2018-11-14 18:37:14 | BioPortfolio

Summary

Repetitive transcranial magnetic stimulation (rTMS) was used to treat methamphetamine use disorder in previous studies, while the evidence-based protocols still required. The aim of this research is to develop more applicable rTMS intervention pattern and protocols to reduce craving and relapse of methamphetamine-dependent patients.

Description

The limbic circuit and executive control circuit are two important frontal-striatal neural circuits associated with drug dependence. Previous studies showed increased functional activity within the limbic neural circuit (e.g. medial prefrontal cortex and ventral striatum) in the presence of a salient cue and decreased activity in the executive control circuit (e.g. dorsal prefrontal cortex and dorsal striatum). TMS was used to reverse the activities of this two circuits, by using continuous TBS and intermittent TBS, respectively. In this study, vmPFC cTBS was conducted to modulating the limbic circuit, while left dlPFC iTBS was conducted to modulating the executive control circuit. Combined treatment of vmPFC cTBS and left dlPFC iTBS was conducted to modulating two circuits simultaneously. Focused on evaluating the efficacy of the interventions and investigate the mechanisms, neuropsychological tests, biochemical tests, and electroencephalography will be used to investigate the neurobiological mechanism of amphetamine use disorder, craving, and relapse. The study will be very helpful to develop evidence-based rTMS protocols for methamphetamine-dependent patients in clinical practice and decrease harm for both the patients and their families.

Study Design

Conditions

Amphetamine Use Disorders

Intervention

sham TBS, real mPFC cTBS, real dlPFC iTBS, real dlPFC iTBS + real mPFC cTBS

Location

Shanghai Compulsory Rehabilitation Center
Shanghai
Shanghai
China
201900

Status

Not yet recruiting

Source

Shanghai Mental Health Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2018-11-14T18:37:14-0500

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