Topics

KP-10 and Insulin Secretion in Men

2018-12-17 03:04:17 | BioPortfolio

Summary

Induction of insulin secretion by kisspeptin is observed in mouse, pig, rat, and human islets in vitro and in rats, mice and monkeys in vivo, but its mechanism is not fully clear. The present study was designed to investigate the role of KP-10 on insulin secretion in adult healthy and obese men with insulin resistance. The aim of selection of obese persons for the present study was to investigate the effect of acute KP-10 administration in a metabolically challenged condition where the pancreatic beta cells are already highly activated. The long-term objective of this study was to understand the physiological role of kisspeptin signalling in the regulation of insulin secretion in human health and disease.

Study Design

Conditions

Kisspeptin Action on Insulin in Healthy Normal Men

Intervention

Kisspeptin-10

Status

Completed

Source

Quaid-e-Azam University

Results (where available)

View Results

Links

Published on BioPortfolio: 2018-12-17T03:04:17-0500

Clinical Trials [2510 Associated Clinical Trials listed on BioPortfolio]

Kisspeptin Influence on Glucose Homeostasis

This study examines how a naturally occurring peptide called Kisspeptin might regulate blood sugar and insulin levels.

Administration of Kisspeptin to Healthy Subjects and Subjects With Reproductive Disorders

The investigators are seeking subjects for a study of the role of kisspeptin in the reproductive system. Kisspeptin is a naturally occuring hormone in humans that stimulates the production...

Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.

The specific objective of this study was to investigate the sensitivity of Kisspeptin receptor 1 (KISS1R) by determining the responsiveness of GnRH neuron to kisspeptin administration acro...

Administration of Kisspeptin in Patients With Hyperprolactinemia

The goal of this project is to explore the use of exogenous pulsatile kisspeptin as a therapeutic alternative for patients with hyperprolactinemia who are intolerant to current therapies.

Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in Men

The present study was designed to assess the responsiveness of the hypothalamic pituitary gonadal axis to kisspeptin administration with increasing age in men.

PubMed Articles [12996 Associated PubMed Articles listed on BioPortfolio]

Kisspeptin and Glucose Homeostasis.

Kisspeptin has well-established critical roles in the control of reproduction and fertility. Recently, evidence has emerged that suggests kisspeptin may have additional roles in the regulation of gluc...

Kisspeptin and Prolactin.

The relationship between elevated prolactin and infertility has been known for a long time, but the specific mechanism by which prolactin inhibited reproduction had been uncertain. The discovery of ki...

Kisspeptin as a potential biomarker throughout pregnancy.

Kisspeptins are a family of neuropeptides that are critical for the puberty initiation and female fertility. Plasma or serum kisspeptin is mainly derived from the placenta during pregnancy and plasma ...

Role of Kisspeptin and NKB in Puberty in Nonhuman Primates: Sex Differences.

To understand the roles of kisspeptin and neurokinin B (NKB) in puberty and sex differences in their involvement, we conducted a series of experiments measuring the release of gonadotropin-releasing h...

Kisspeptin and neurokinin B analogs use in gynecological endocrinology: where do we stand?

Recent studies have found that kisspeptin/neurokinin B/dynorphin neurons (KNDy neurons) in the infundibular nucleus play a crucial role in the reproductive axis. Analogs, both agonists and antagonists...

Medical and Biotech [MESH] Definitions

G protein coupled receptors for the C-terminally amidated peptide of KISSPEPTIN-1. KISS1R plays an essential role in sexual development during puberty through its regulation of GONADOTROPIN-released hormones.

Compounds which inhibit or antagonize the biosynthesis or action of insulin.

A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.

Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS. It can be caused by the presence of INSULIN ANTIBODIES or the abnormalities in insulin receptors (RECEPTOR, INSULIN) on target cell surfaces. It is often associated with OBESITY; DIABETIC KETOACIDOSIS; INFECTION; and certain rare conditions. (from Stedman, 25th ed)

An insulin preparation that is designed to provide immediate and long term glycemic control in a single dosage. Biphasic insulin typically contains a mixture of REGULAR INSULIN or SHORT-ACTING INSULIN combined with a LONG-ACTING INSULIN.

More From BioPortfolio on "KP-10 and Insulin Secretion in Men"

Quick Search

Relevant Topic

Endocrine Disorders
Endocrine disorders are grouped into two categories: hormone imbalance - when a gland produces too much or too little of an endocrine hormone development of lesions (such as nodules or tumors) in the endocrine system, which may or may not affect...


Searches Linking to this Trial