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Reversal of Dual Antiplatelet Therapy With Cold Stored Platelets

2019-01-07 10:17:19 | BioPortfolio

Published on BioPortfolio: 2019-01-07T10:17:19-0500

Clinical Trials [3683 Associated Clinical Trials listed on BioPortfolio]

Transfusion of Cold-stored Platelet Concentrates

This study will investigate the effects of Leukocyte reduced cold-stored platelet transfusions used in treatment of immediate postoperative blood loss in patients undergoing thoracic surge...

A Randomized, Multi-center, Open-label, Paired Controlled, Crossover In Vivo Study

The objective of this study is to test the hypothesis that INTERCEPT Blood System for platelet components stored for 6 or 7 days after INTERCEPT Blood System treatment retain sufficient vi...

Cold Apheresis Platelets in Isoplate

This is a platelet transfusion study. The purpose of this study is to measure the life span and quality of platelets preserved in an additive solution and stored in a refrigerator. Partici...

Comparing Fresh Random Platelets and Autologous Cryopreserved Thrombosol Treated Autologous Platelets

Objectives: - Determine the corrected count increment of autologous transfused platelets that had been stored by cryopreservation with ThromboSol. - Determine the abilit...

A Controlled, In Vivo, Pilot Study to Assess the Recovery and Survival of Radiolabeled Autologous INTERCEPT Treated 7-Day Stored Apheresis Platelet Components in 35% Plasma and 65% InterSol and 7-Day Stored Apheresis Platelet Components in 100% Plasma

The objective of this study is to test the hypothesis that INTERCEPT platelet components stored for 7 days retain sufficient viability for therapeutic efficacy. The post-infusion recovery ...

PubMed Articles [7301 Associated PubMed Articles listed on BioPortfolio]

Platelet enhancement of bacterial growth during room temperature storage: mitigation through refrigeration.

Due to high risk of septic transfusion reactions arising from bacterial contamination, US Food and Drug Administration regulations currently limit platelet storage to 5 days at room temperature (RT). ...

Future of platelet formulations with improved clotting profile: a short review on human safety and efficacy data.

Platelet (PLT) transfusion is a widely used therapy in treating or preventing bleeding and hemorrhage in patients with thrombocytopenia or trauma. Compared to the relative ease of PLT transfusion, cur...

Fatal acute hemolytic transfusion reaction due to anti-B from a platelet apheresis unit stored in platelet additive solution.

Hemolytic transfusion reactions from out-of-group plasma in platelet (PLT) transfusions are uncommon, with most involving passive transfer of anti-A. Only rare reactions have ever been reported due to...

Platelet-Rich Plasma and Platelet-Rich Fibrin Enhance the Outcomes of Fat Grafting: A Comparative Study.

Autologous fat grafting is an efficient procedure in plastic surgery. However, its long-term tissue absorption is variable and technique-dependent. Platelet-rich plasma positively affects fat-grafting...

Metabolic and neurobehavioral response following intraovarian administration of autologous activated platelet rich plasma: First qualitative data.

This work assessed sexual and neurobehavioral parameters after ovarian treatment with autologous PRP.

Medical and Biotech [MESH] Definitions

Human alloantigens expressed only on platelets, specifically on platelet membrane glycoproteins. These platelet-specific antigens are immunogenic and can result in pathological reactions to transfusion therapy.

Disorder characterized by a decrease or lack of platelet dense bodies in which the releasable pool of adenine nucleotides and 5HT are normally stored.

A rare, inherited platelet disorder characterized by a selective deficiency in the number and contents of platelet alpha-granules. It is associated with THROMBOCYTOPENIA, enlarged platelets, and prolonged bleeding time.

Reinfusion of blood or blood products derived from the patient's own circulation. (Dorland, 27th ed)

Platelet membrane glycoprotein IIb is an integrin alpha subunit that heterodimerizes with INTEGRIN BETA3 to form PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX. It is synthesized as a single polypeptide chain which is then postranslationally cleaved and processed into two disulfide-linked subunits of approximately 18 and 110 kDa in size.

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