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Treatment of Cytomegalovirus (CMV) Infections With Viral-Specific T Cells

2019-01-15 13:04:16 | BioPortfolio

Published on BioPortfolio: 2019-01-15T13:04:16-0500

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Clinical Grade Adenovirus Specific T Cells for Immunotherapy After Allogeneic Stem Cell Transplantation (CTL-ADV)

Fourteen patients will be included for infusion of adenovirus-specific T-cells generated by a clinical grade IFN-γ based immunomagnetic isolation from a leukapheresis from their original ...

Efficacy Study of T Cell Vaccination in HIV Infection

The hallmark of HIV infection and AIDS is the continuous attrition of CD4 T cells. One of the mechanisms that may account for the CD4 attrition , is autoimmunity against the CD4 T cells, ...

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Emergency Use of Adoptive Immunotherapy With CMV-Specific T Cells After Donor Bone Marrow Transplant of an Infant With Immunodeficiency Syndrome and CMV Infection

RATIONALE: Collecting the T cells from a donor and transplanting them into a patient may be effective treatment for immunodeficiency syndrome and CMV infection. PURPOSE: This clinical tri...

Antigen Specific Adoptive T Cell Therapy for Adenovirus Infection After Hematopoietic Stem Cell Transplantation

The purpose of this study is to determine if it is possible to treat an infection with a cell-based immunotherapy (therapy that uses the patient's own immune system to treat the infection)...

PubMed Articles [26950 Associated PubMed Articles listed on BioPortfolio]

Chemokine-regulated recruitment of antigen-specific T cell sub-populations to the liver in acute and chronic hepatitis C infection.

In hepatitis C virus (HCV) infection, virus-specific CD8+ T cells are recruited to the liver for antiviral activity. Multiple chemokine ligands are induced by the infection, notably interferon-inducib...

HIV Interferes with the Dendritic Cell-T Cell Axis of Macrophage Activation by Shifting -Specific CD4 T Cells into a Dysfunctional Phenotype.

HIV coinfection is the greatest risk factor for transition of latent infection into active tuberculosis (TB). Epidemiological data reveal both the reduction and the impairment of -specific CD4 T cell...

-specific atypical memory B cells are short-lived activated B cells.

A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived me...

Temporal Requirement for Pulmonary Resident and Circulating T Cells during Virulent Infection.

The lung is a complex organ with anatomically distinct pools of T cells that play specific roles in combating infection. Our knowledge regarding the generation and/or maintenance of immunity by parenc...

Phenotype and function of HBV-specific T cells is determined by the targeted epitope in addition to the stage of infection.

Chronic HBV infection affects more than 250 million people worldwide and remains a global healthcare problem in part because we lack curative treatment. Sustained viral control requires HBV-specific...

Medical and Biotech [MESH] Definitions

An infection at a specific location that may spread to another region of the body.

The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.

CXCR receptors that are specific for CHEMOKINE CXCL16. They are expressed by lymphoid tissues, activated T-cells, and also function as co-receptors for SIMIAN IMMUNODEFICIENCY VIRUSES; HIV-2; and HIV-1 infection of MACROPHAGES.

A phenomenon in which infection by a first virus results in resistance of cells or tissues to infection by a second, unrelated virus.

Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.

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