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Neuroimmune Effects of Opioid Administration

2019-01-17 13:16:19 | BioPortfolio

Summary

In this study, a novel human laboratory model will be evaluated. Acute opioid-induced neuroimmune responses will be quantified among healthy volunteers (Specific Aim). To measure the neuroimmune system, we will use [11C]PBR28 positron emission tomography (PET) imaging to quantify 18kDa translocator protein (TSPO) levels. TSPO is an imaging marker of the neuroimmune system thought to reflect microglia levels. Up to twenty healthy volunteers will complete two 120-minute [11C]PBR28 PET scans. One scan will take place prior to a single morphine administration (0.07 mg/kg i.m.) and the second scan will be will start approximately 2-hours post-injection.

Specific Aim: To determine whether an acute morphine injection increases TSPO availability in healthy volunteers.

Hypothesis: Relative to baseline, morphine will significantly increase whole-brain TSPO availability, consistent with a neuroimmune response.

Study Design

Conditions

Microgliosis

Intervention

Intramuscular Morphine

Status

Not yet recruiting

Source

Yale University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-01-17T13:16:19-0500

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Medical and Biotech [MESH] Definitions

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.

Strong dependence, both physiological and emotional, upon morphine.

Analogs or derivatives of morphine.

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.

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