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Efficacy and Safety of Erenumab in Pediatric Subjects With Episodic Migraine

2019-02-14 21:13:10 | BioPortfolio

Published on BioPortfolio: 2019-02-14T21:13:10-0500

Clinical Trials [12059 Associated Clinical Trials listed on BioPortfolio]

Efficacy and Safety of Erenumab in Pediatric Subjects With Chronic Migraine

This study will evaluate the efficacy and safety of erenumab in migraine prevention in children (6 to

A Controlled Trial of Erenumab in Migraine Prevention

Study is a phase 3 confirmatory trial intended to assess the efficacy and safety of erenumab for prevention of migraine in Japanese subjects with episodic migraine (EM) and chronic migrain...

Imaging the Migraine Brain Pre- and Post-Erenumab

The aims of this study are to: 1. Identify changes in brain function and structure that correlate with response to erenumab. 2. Develop models using imaging data +/- clini...

Head-to-head Study of Erenumab Against Topiramate in Patients With Episodic Migraine

The purpose of this study is to determine the safety and efficacy of 70 mg and 140 mg AMG 334 compared to topiramate in the highest tolerated dose in patients suffering from 4 - 14 migrain...

Study of Efficacy and Safety of AMG 334 in Adult Episodic Migraine Patients

The purpose of this study is to evaluate the efficacy and safety of AMG334 in countries beyond the United States (US) and European Union (EU).

PubMed Articles [6181 Associated PubMed Articles listed on BioPortfolio]

CGRP Antibodies as Prophylaxis in Migraine.

Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (CLR + RAMP1) offer considerable improvements over existing drugs in migraine prophylaxis and are the first designe...

History and Review of anti-Calcitonin Gene-Related Peptide (CGRP) Therapies: From Translational Research to Treatment.

Objective - To briefly describe the history of and available data on anti-calcitonin gene-related peptide (CGRP) therapies for headache. Background - CGRP was proposed as a target for primary headache...

Drug updates and approvals: 2018 in review.

In 2018, the FDA approved several new drugs for use in primary care. This article highlights the following new drugs: bictegravir, emtricitabine, and tenofovir alafenamide (Biktarvy); doxylamine succi...

Tumor Voxel Dose Response Matrix and Dose Prescription Function Derived Using F-FDG PET/CT Images for Adaptive Dose Painting by Number.

To construct a tumor voxel Dose Response Matrix (DRM) and Dose Prescription Function (DPF) for adaptive Dose Painting by Number (DPbN) based on treatment feedback of FDG-PET/CT imaging.

Half-Dose Versus Full-Dose Alteplase for Treatment of Pulmonary Embolism.

Recent evidence suggests that half-dose thrombolysis for pulmonary embolism may provide similar efficacy with reduced bleeding risk compared with full-dose therapy, but comparative studies are lacking...

Medical and Biotech [MESH] Definitions

The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

A treatment schedule in which the total dose of radiation is divided into large doses.

The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)

Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.

The ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response.

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